Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4191855..4192474 Replicon chromosome
Accession NZ_CP082029
Organism Klebsiella pneumoniae strain KP18-2113

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag K6164_RS20370 Protein ID WP_002892050.1
Coordinates 4192256..4192474 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag K6164_RS20365 Protein ID WP_002892066.1
Coordinates 4191855..4192229 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6164_RS20355 (4187007) 4187007..4188200 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K6164_RS20360 (4188223) 4188223..4191369 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
K6164_RS20365 (4191855) 4191855..4192229 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
K6164_RS20370 (4192256) 4192256..4192474 + 219 WP_002892050.1 HHA domain-containing protein Toxin
K6164_RS20375 (4192633) 4192633..4193199 + 567 WP_002892030.1 maltose O-acetyltransferase -
K6164_RS20380 (4193171) 4193171..4193311 - 141 WP_004147370.1 hypothetical protein -
K6164_RS20385 (4193332) 4193332..4193802 + 471 WP_002892026.1 YlaC family protein -
K6164_RS20390 (4193777) 4193777..4195228 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
K6164_RS20395 (4195329) 4195329..4196027 + 699 WP_002892021.1 GNAT family protein -
K6164_RS20400 (4196024) 4196024..4196164 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
K6164_RS20405 (4196164) 4196164..4196427 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T214021 WP_002892050.1 NZ_CP082029:4192256-4192474 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T214021 NZ_CP109940:719560-720837 [Streptococcus suis]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAGCTTTATGAAAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGGTATAATTTGGTGATCGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAT
CTAAAGGTTATGAAACAAAAATATACGTCATGGCAGTACCGAAAATTGAATCATACTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GCTTAGAAACGCCTTCCATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGGTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
AGCTAATAAAGACCGCCCTCAGTTACAAGCTATGCTTGCTTATATACGTGAAGGTGATATAGTGGTTGTGACAGAATTAG
AACGCCTGGGTAGGAATAACAAGGAGCTAACTGAGGTCATGAATGATATTCAAGCCAAGGGGGCAACCTTGGAAGTCTTA
AATCTTCCCACTCTTCGAGGGATTGAGGATGACAACCTGAGACGGCTCTTGAACAATCTTATCCTGGAACTCTACAAGTA
CCAGGCACAAGCTGAAAGGGAACGCATAAAGGAACGGCAACGCCAAGGGATAGCTATTGCCAAGACTCAAGGAAAGTACA
AAGGCAGAAAAGCCATTTTTTCAGAAGATGACAGCAGGCTTCTTCATGCCTTTGACCTTTACCTTGAAGGTCTATCAGAT
AAAGACGTTGCCAAGCTAACAGGTATCAACGAACGTACTTTTAGGCGGTATCGTGAAAAGCATAAGATAAAAAGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT214021 WP_002892066.1 NZ_CP082029:4191855-4192229 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT214021 NZ_CP109940:719286-719558 [Streptococcus suis]
ATGGCAGTTACGTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References