Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1016055..1016712 Replicon chromosome
Accession NZ_CP082029
Organism Klebsiella pneumoniae strain KP18-2113

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag K6164_RS05170 Protein ID WP_002916310.1
Coordinates 1016302..1016712 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K6164_RS05165 Protein ID WP_002916312.1
Coordinates 1016055..1016321 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6164_RS05140 (1011211) 1011211..1012644 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
K6164_RS05145 (1012763) 1012763..1013491 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K6164_RS05150 (1013541) 1013541..1013852 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
K6164_RS05155 (1014016) 1014016..1014675 + 660 WP_002916317.1 hemolysin III family protein -
K6164_RS05160 (1014826) 1014826..1015809 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
K6164_RS05165 (1016055) 1016055..1016321 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K6164_RS05170 (1016302) 1016302..1016712 + 411 WP_002916310.1 protein YgfX Toxin
K6164_RS05175 (1016719) 1016719..1017240 - 522 WP_004144730.1 flavodoxin FldB -
K6164_RS05180 (1017341) 1017341..1018237 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K6164_RS05185 (1018260) 1018260..1018973 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K6164_RS05190 (1018979) 1018979..1020712 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T214010 WP_002916310.1 NZ_CP082029:1016302-1016712 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T214010 NZ_CP109933:2801667-2802029 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT214010 WP_002916312.1 NZ_CP082029:1016055-1016321 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT214010 NZ_CP109933:2801500-2801670 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References