214008

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 848549..849459 Replicon chromosome
Accession NZ_CP082029
Organism Klebsiella pneumoniae strain KP18-2113

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag K6164_RS04315 Protein ID WP_004026354.1
Coordinates 848549..849019 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2J4RLY9
Locus tag K6164_RS04320 Protein ID WP_004181895.1
Coordinates 849016..849459 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6164_RS04295 (844882) 844882..845640 + 759 Protein_836 putrescine ABC transporter permease SapB -
K6164_RS04300 (845683) 845683..846387 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
K6164_RS04305 (846412) 846412..847608 + 1197 WP_119062602.1 IS481 family transposase -
K6164_RS04310 (848179) 848179..848439 + 261 WP_004026352.1 hypothetical protein -
K6164_RS04315 (848549) 848549..849019 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
K6164_RS04320 (849016) 849016..849459 - 444 WP_004181895.1 DUF2384 domain-containing protein Antitoxin
K6164_RS04325 (849560) 849560..850831 - 1272 WP_004181894.1 translesion error-prone DNA polymerase V subunit UmuC -
K6164_RS04330 (850831) 850831..851253 - 423 WP_004181893.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
K6164_RS04335 (851339) 851339..852826 - 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -
K6164_RS04340 (853339) 853339..853593 + 255 WP_016946352.1 Hha/YmoA family nucleoid-associated regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T214008 WP_004026354.1 NZ_CP082029:c849019-848549 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T214008 NZ_CP109933:2724685-2724789 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16536.87 Da        Isoelectric Point: 10.3013

>AT214008 WP_004181895.1 NZ_CP082029:c849459-849016 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT214008 NZ_CP109933:c2724947-2724784 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4RLY9

References