Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 735260..735786 Replicon chromosome
Accession NZ_CP082029
Organism Klebsiella pneumoniae strain KP18-2113

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag K6164_RS03680 Protein ID WP_000323025.1
Coordinates 735260..735547 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag K6164_RS03685 Protein ID WP_000534858.1
Coordinates 735547..735786 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6164_RS03650 (730306) 730306..730539 - 234 WP_004181905.1 hypothetical protein -
K6164_RS03655 (730618) 730618..730965 - 348 WP_004181904.1 hypothetical protein -
K6164_RS03660 (731121) 731121..732188 - 1068 WP_004181903.1 hypothetical protein -
K6164_RS03665 (732878) 732878..733255 + 378 WP_004181901.1 hypothetical protein -
K6164_RS03670 (733453) 733453..734427 - 975 WP_004181899.1 hypothetical protein -
K6164_RS03675 (735030) 735030..735188 - 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
K6164_RS03680 (735260) 735260..735547 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
K6164_RS03685 (735547) 735547..735786 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
K6164_RS28235 (735811) 735811..735915 + 105 Protein_713 hypothetical protein -
K6164_RS03690 (736049) 736049..736372 - 324 WP_224948387.1 cation transporter dimerization domain-containing protein -
K6164_RS03695 (736538) 736538..737706 + 1169 WP_085929673.1 IS3-like element ISEc52 family transposase -
K6164_RS03700 (737767) 737767..739050 + 1284 WP_223819051.1 DEAD/DEAH box helicase -
K6164_RS03705 (739318) 739318..739932 - 615 WP_004026303.1 lytic transglycosylase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element aac(3)-IId / blaSHV-187 / mph(E) / msr(E) / armA / sul1 / blaDHA-1 / qnrB4 fimA / fimI / fimC / fimD / fimD / fimF / fimG / rmpA / iutA / iucD / iucC / iucB / iucA 579774..844483 264709


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T214006 WP_000323025.1 NZ_CP082029:c735547-735260 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T214006 NZ_CP109933:2441496-2441603 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT214006 WP_000534858.1 NZ_CP082029:c735786-735547 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT214006 NZ_CP109933:c2441680-2441620 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References