214006

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 735260..735786 Replicon chromosome
Accession NZ_CP082029
Organism Klebsiella pneumoniae strain KP18-2113

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag K6164_RS03680 Protein ID WP_000323025.1
Coordinates 735260..735547 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag K6164_RS03685 Protein ID WP_000534858.1
Coordinates 735547..735786 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6164_RS03650 (730306) 730306..730539 - 234 WP_004181905.1 hypothetical protein -
K6164_RS03655 (730618) 730618..730965 - 348 WP_004181904.1 hypothetical protein -
K6164_RS03660 (731121) 731121..732188 - 1068 WP_004181903.1 hypothetical protein -
K6164_RS03665 (732878) 732878..733255 + 378 WP_004181901.1 hypothetical protein -
K6164_RS03670 (733453) 733453..734427 - 975 WP_004181899.1 hypothetical protein -
K6164_RS03675 (735030) 735030..735188 - 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
K6164_RS03680 (735260) 735260..735547 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
K6164_RS03685 (735547) 735547..735786 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
K6164_RS28235 (735811) 735811..735915 + 105 Protein_713 hypothetical protein -
K6164_RS03690 (736049) 736049..736372 - 324 WP_224948387.1 cation transporter dimerization domain-containing protein -
K6164_RS03695 (736538) 736538..737706 + 1169 WP_085929673.1 IS3-like element ISEc52 family transposase -
K6164_RS03700 (737767) 737767..739050 + 1284 WP_223819051.1 DEAD/DEAH box helicase -
K6164_RS03705 (739318) 739318..739932 - 615 WP_004026303.1 lytic transglycosylase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element aac(3)-IId / blaSHV-187 / mph(E) / msr(E) / armA / sul1 / blaDHA-1 / qnrB4 fimA / fimI / fimC / fimD / fimD / fimF / fimG / rmpA / iutA / iucD / iucC / iucB / iucA 579774..844483 264709


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T214006 WP_000323025.1 NZ_CP082029:c735547-735260 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T214006 NZ_CP109933:2441496-2441603 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT214006 WP_000534858.1 NZ_CP082029:c735786-735547 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT214006 NZ_CP109933:c2441680-2441620 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References