Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4212159..4212778 Replicon chromosome
Accession NZ_CP082024
Organism Klebsiella pneumoniae strain KP18-2073

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag K6166_RS20950 Protein ID WP_002892050.1
Coordinates 4212560..4212778 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag K6166_RS20945 Protein ID WP_002892066.1
Coordinates 4212159..4212533 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6166_RS20935 4207311..4208504 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K6166_RS20940 4208527..4211673 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
K6166_RS20945 4212159..4212533 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
K6166_RS20950 4212560..4212778 + 219 WP_002892050.1 HHA domain-containing protein Toxin
K6166_RS20955 4212937..4213503 + 567 WP_002892030.1 maltose O-acetyltransferase -
K6166_RS20960 4213475..4213615 - 141 WP_004147370.1 hypothetical protein -
K6166_RS20965 4213636..4214106 + 471 WP_002892026.1 YlaC family protein -
K6166_RS20970 4214081..4215532 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
K6166_RS20975 4215633..4216331 + 699 WP_002892021.1 GNAT family protein -
K6166_RS20980 4216328..4216468 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
K6166_RS20985 4216468..4216731 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T213986 WP_002892050.1 NZ_CP082024:4212560-4212778 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T213986 NZ_CP109931:2421907-2422317 [Pseudomonas aeruginosa]
ATGCTCAAGTTCATGCTTGACACCAACATCTGCATCTTCACCATCAAAAACCGCCCGCAAGAGGTGCGCGAGGCGTTCCT
GCGCCACCACGACCAGATGTGCATCAGCACCGTGACGCTGATGGAGCTGATCTACGGCGCAGAGAAGTCCTCGAACCCCT
CGCGCAATCTTGCAGACGTGGAAGGCTTCGCTGCTCGTCTGGAGGTGCTCAAGTACGACCAGGAAGCTGCCGCCCACACC
GGCCAGCTCCGCGCTGAACTGGCCCGCCTCGGGAAGCAAATCGGCCCCTATGACCAGATGATCGCCGGGCACGCCCGCTC
TCAGGGCCTGATCGTGGTCACCAATAACCGCCGCGAGTTCGACCGCGTACCCGGCTTGAGAGTTGAGGATTGGGTCGCCC
CAATCGTGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT213986 WP_002892066.1 NZ_CP082024:4212159-4212533 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT213986 NZ_CP109931:2421677-2421907 [Pseudomonas aeruginosa]
GTGGAACAAGGTTCTGTTTTTCAGAGCAATCGTAGCCAGGCCGTAAGACTGCCCAAGGCCGTCGCGCTTCCTGATGACGT
TAAGCGTGTGGATGTGGTCGCTGTGGGGCGCGCCAGAATCATCACGCCTGCCGGCGAGTCTTGGGATAGCTGGTTCGATG
GCGAGGGCGTTACTGCCGACTTTATGGCTGAGCGTGAACAGCCTGCCGATCAGGAGCGCGAGACTTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References