Detailed information of TA system TA021396

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1154495..1155104
• Replicon: chromosome
• Accession: NC_007712
• Organism: Sodalis glossinidius str. morsitans

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: W0HVX7
• Locus tag: SGP1_RS05830
• Protein ID: WP_011410544.1
• Coordinates: 1154495..1154698 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: Q2NV68
• Locus tag: SGP1_RS05835
• Protein ID: WP_011410545.1
• Coordinates: 1154745..1155104 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SGP1_RS05810 (SG0679)	1150797..1151135	+	339	WP_011410542.1	P-II family nitrogen regulator	-
SGP1_RS05815 (SG0680)	1151173..1152402	+	1230	Protein_1228	ammonium transporter	-
SGP1_RS05820	1152660..1153210	+	551	Protein_1229	YbaY family lipoprotein	-
SGP1_RS05825	1153405..1153707	-	303	WP_041866665.1	MGMT family protein	-
SGP1_RS05830 (SG0681)	1154495..1154698	-	204	WP_011410544.1	HHA domain-containing protein	Toxin
SGP1_RS05835 (SG0682)	1154745..1155104	-	360	WP_011410545.1	Hha toxicity modulator TomB	Antitoxin
SGP1_RS05840 (SG0683)	1155621..1155761	-	141	WP_011410546.1	type B 50S ribosomal protein L36	-
SGP1_RS05845	1155781..1156037	-	257	Protein_1234	type B 50S ribosomal protein L31	-
SGP1_RS05850 (SG0684)	1156190..1159354	-	3165	WP_011410547.1	efflux RND transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-118)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8150.53 Da
• Isoelectric Point: 8.8913

>T21396 WP_011410544.1 NC_007712:c1154698-1154495 [Sodalis glossinidius str. 'morsitans']
MKKIDYLMRLRKCRTLETLERVIEKNKYELSDDELEIFNSAADHRLAELTMNKLYDKVPVSVWKYVR

Nucleotide

• Length: 204 bp

>T21396 NC_007712:c1154698-1154495 [Sodalis glossinidius str. 'morsitans']
ATGAAAAAGATCGACTATTTAATGCGCTTGAGGAAGTGCAGAACGCTGGAAACCCTTGAGCGTGTGATTGAAAAAAACAA
ATATGAACTGTCCGATGACGAGCTAGAGATATTCAATTCCGCCGCCGATCATCGTCTGGCGGAACTGACGATGAACAAGC
TATACGACAAAGTACCGGTTTCCGTCTGGAAGTATGTACGCTAA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13944.47 Da
• Isoelectric Point: 4.5701

>AT21396 WP_011410545.1 NC_007712:c1155104-1154745 [Sodalis glossinidius str. 'morsitans']
MDEYSPKRYDIAQLKYLCENLYDEGIASLGNSYHGWVNDPSSAVNLQLNELIEHIAANIVIFKLKYHNESELTDQAETFL
DDTFTLFSSYGINNYDIQRWRRSRRRLFGTFSETELCTT

Nucleotide

• Length: 360 bp

>AT21396 NC_007712:c1155104-1154745 [Sodalis glossinidius str. 'morsitans']
ATGGATGAGTATTCACCCAAACGCTACGATATTGCGCAATTGAAATACCTGTGTGAAAATCTCTATGATGAAGGCATTGC
CAGTCTGGGCAACAGCTATCATGGTTGGGTAAATGACCCAAGTTCCGCCGTCAATTTGCAGCTTAACGAATTAATTGAGC
ACATAGCGGCGAATATTGTCATCTTCAAACTTAAATACCATAATGAAAGTGAGCTTACCGATCAGGCTGAAACCTTTTTA
GACGATACTTTTACCCTGTTCAGTAGCTATGGCATCAATAATTACGATATACAGCGCTGGCGGCGCAGCCGCAGGCGTTT
ATTCGGAACATTCTCGGAGACAGAGCTCTGTACAACCTGA

Structures

Toxin

• AlphaFold DB: W0HVX7

Antitoxin

• AlphaFold DB: Q2NV68