213958

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5065212..5065738 Replicon chromosome
Accession NZ_CP082019
Organism Klebsiella pneumoniae strain KP18-2050

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag K6159_RS25095 Protein ID WP_000323025.1
Coordinates 5065451..5065738 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag K6159_RS25090 Protein ID WP_000534858.1
Coordinates 5065212..5065451 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6159_RS25065 5060274..5060978 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
K6159_RS25070 5061210..5062550 + 1341 WP_000589001.1 ISNCY family transposase -
K6159_RS25075 5062971..5063282 + 312 Protein_4923 transposase -
K6159_RS25085 5064626..5064949 + 324 WP_224948387.1 cation transporter dimerization domain-containing protein -
K6159_RS30240 5065083..5065187 - 105 Protein_4926 hypothetical protein -
K6159_RS25090 5065212..5065451 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
K6159_RS25095 5065451..5065738 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
K6159_RS25100 5065810..5065968 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
K6159_RS25105 5066571..5067545 + 975 WP_004181899.1 hypothetical protein -
K6159_RS25110 5067743..5068120 - 378 WP_004181901.1 hypothetical protein -
K6159_RS25115 5068810..5069877 + 1068 WP_004181903.1 hypothetical protein -
K6159_RS25120 5070033..5070380 + 348 WP_004181904.1 hypothetical protein -
K6159_RS25125 5070459..5070692 + 234 WP_004181905.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element blaSHV-187 / aph(3')-Ia / tet(A) iucA / iucB / iucC / iucD / iutA / rmpA 5049220..5247472 198252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T213958 WP_000323025.1 NZ_CP082019:5065451-5065738 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T213958 NZ_CP109924:c4313999-4313649 [Escherichia coli O125ac:K+:H10]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCCACGCGCCCGACTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT213958 WP_000534858.1 NZ_CP082019:5065212-5065451 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT213958 NZ_CP109924:c4314244-4313993 [Escherichia coli O125ac:K+:H10]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References