Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 5065212..5065738 | Replicon | chromosome |
Accession | NZ_CP082019 | ||
Organism | Klebsiella pneumoniae strain KP18-2050 |
Toxin (Protein)
Gene name | relE | Uniprot ID | S1EXL1 |
Locus tag | K6159_RS25095 | Protein ID | WP_000323025.1 |
Coordinates | 5065451..5065738 (+) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | S1F6D3 |
Locus tag | K6159_RS25090 | Protein ID | WP_000534858.1 |
Coordinates | 5065212..5065451 (+) | Length | 80 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K6159_RS25065 | 5060274..5060978 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
K6159_RS25070 | 5061210..5062550 | + | 1341 | WP_000589001.1 | ISNCY family transposase | - |
K6159_RS25075 | 5062971..5063282 | + | 312 | Protein_4923 | transposase | - |
K6159_RS25085 | 5064626..5064949 | + | 324 | WP_224948387.1 | cation transporter dimerization domain-containing protein | - |
K6159_RS30240 | 5065083..5065187 | - | 105 | Protein_4926 | hypothetical protein | - |
K6159_RS25090 | 5065212..5065451 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
K6159_RS25095 | 5065451..5065738 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
K6159_RS25100 | 5065810..5065968 | + | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
K6159_RS25105 | 5066571..5067545 | + | 975 | WP_004181899.1 | hypothetical protein | - |
K6159_RS25110 | 5067743..5068120 | - | 378 | WP_004181901.1 | hypothetical protein | - |
K6159_RS25115 | 5068810..5069877 | + | 1068 | WP_004181903.1 | hypothetical protein | - |
K6159_RS25120 | 5070033..5070380 | + | 348 | WP_004181904.1 | hypothetical protein | - |
K6159_RS25125 | 5070459..5070692 | + | 234 | WP_004181905.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integrative and Conjugative Element | blaSHV-187 / aph(3')-Ia / tet(A) | iucA / iucB / iucC / iucD / iutA / rmpA | 5049220..5247472 | 198252 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T213958 WP_000323025.1 NZ_CP082019:5065451-5065738 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T213958 NZ_CP109924:c4313999-4313649 [Escherichia coli O125ac:K+:H10]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCCACGCGCCCGACTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCCACGCGCCCGACTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT213958 WP_000534858.1 NZ_CP082019:5065212-5065451 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT213958 NZ_CP109924:c4314244-4313993 [Escherichia coli O125ac:K+:H10]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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