213955

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4220436..4221055 Replicon chromosome
Accession NZ_CP082019
Organism Klebsiella pneumoniae strain KP18-2050

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag K6159_RS21005 Protein ID WP_002892050.1
Coordinates 4220837..4221055 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag K6159_RS21000 Protein ID WP_002892066.1
Coordinates 4220436..4220810 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6159_RS20990 4215588..4216781 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K6159_RS20995 4216804..4219950 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
K6159_RS21000 4220436..4220810 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
K6159_RS21005 4220837..4221055 + 219 WP_002892050.1 HHA domain-containing protein Toxin
K6159_RS21010 4221214..4221780 + 567 WP_002892030.1 maltose O-acetyltransferase -
K6159_RS21015 4221752..4221892 - 141 WP_004147370.1 hypothetical protein -
K6159_RS21020 4221913..4222383 + 471 WP_002892026.1 YlaC family protein -
K6159_RS21025 4222358..4223809 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
K6159_RS21030 4223910..4224608 + 699 WP_002892021.1 GNAT family protein -
K6159_RS21035 4224605..4224745 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
K6159_RS21040 4224745..4225008 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T213955 WP_002892050.1 NZ_CP082019:4220837-4221055 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T213955 NZ_CP109924:3934895-3935272 [Escherichia coli O125ac:K+:H10]
ATGCAAACCCAACCACTATCCTCAACGCAGGAGGCTACATCACGCCCGTCACCGGTGGAGATCTGGCAACAGCTTCTGAG
CCACCTGTTGGATCGTCACTACGGTCTGACGCTTAACGACACGCCGTTTGGCAACGACGGTGTGATTCAGGAGCATATCG
ACGCCGGTATATCACTGTGCGACGCCGTGAATTTTATTGTGGAGAAGTACGATCTGGTGCGCATCGATCGTCACGGTTTC
AGTACAGAAACACAGTTGCCGCGTCTCACCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGGTTGATGACTCGCAA
CGATTACAGAACGGTGACCGACATCACCACCGGTAAATACCGTGGGGGGCATCGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT213955 WP_002892066.1 NZ_CP082019:4220436-4220810 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT213955 NZ_CP109924:3934485-3934844 [Escherichia coli O125ac:K+:H10]
TTGTCGAATAAAACACCGATAGTAAACCACGATGTCACTGAACCCTGGTGGGGGCTTAAACGCAGTATCACGCCCTGTTT
TGGCGTACGGCTGGTGCAGGCGGGCAACTGTCTGCATTATCTCGCTGACCGGGCCAGCATCACCGGACAGTTCAGCGACG
CGGATTTACGGCATCTCGACCAGGCATTTCCACTGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCACT
CCCCGCCATCAGCACTGTGTCACGCTCTATGCAAAAGGGCTGACCTGCGAGGCCGACTCCCTCGGCTCGCATGGTTACGT
ATACCTGGCGATTTATCCGACACCAGCGGCAACCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References