Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pasABC/RelE-HTH |
| Location | 3644..4118 | Replicon | plasmid pKP18-238-4 |
| Accession | NZ_CP082017 | ||
| Organism | Klebsiella pneumoniae strain KP18-238 | ||
Toxin (Protein)
| Gene name | pasB | Uniprot ID | A0A8J3DT22 |
| Locus tag | K6162_RS29105 | Protein ID | WP_004197762.1 |
| Coordinates | 3852..4118 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | pasA | Uniprot ID | S1EJF5 |
| Locus tag | K6162_RS29100 | Protein ID | WP_000879771.1 |
| Coordinates | 3644..3868 (+) | Length | 75 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6162_RS29075 | 1061..1237 | + | 177 | WP_004197757.1 | hypothetical protein | - |
| K6162_RS29080 | 1227..1571 | + | 345 | WP_062955149.1 | MobC family plasmid mobilization relaxosome protein | - |
| K6162_RS29535 | 1780..2214 | + | 435 | Protein_2 | relaxase/mobilization nuclease domain-containing protein | - |
| K6162_RS29090 | 2249..2758 | + | 510 | WP_032433972.1 | MbeB family mobilization protein | - |
| K6162_RS29095 | 2765..2977 | + | 213 | WP_021527181.1 | MbeD family mobilization/exclusion protein | - |
| K6162_RS29540 | 3353..3481 | - | 129 | WP_000523570.1 | hypothetical protein | - |
| K6162_RS29100 | 3644..3868 | + | 225 | WP_000879771.1 | DUF6290 family protein | Antitoxin |
| K6162_RS29105 | 3852..4118 | + | 267 | WP_004197762.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K6162_RS29110 | 4188..4538 | - | 351 | WP_004197756.1 | hypothetical protein | - |
| K6162_RS29115 | 4604..5149 | - | 546 | WP_023317533.1 | hypothetical protein | - |
| K6162_RS29120 | 5175..5501 | - | 327 | WP_050516389.1 | hypothetical protein | - |
| K6162_RS29125 | 6657..6833 | + | 177 | WP_004197757.1 | hypothetical protein | - |
| K6162_RS29130 | 6823..7167 | + | 345 | WP_062955149.1 | MobC family plasmid mobilization relaxosome protein | - |
| K6162_RS29545 | 7376..7810 | + | 435 | Protein_13 | relaxase/mobilization nuclease domain-containing protein | - |
| K6162_RS29140 | 7845..8354 | + | 510 | WP_032433972.1 | MbeB family mobilization protein | - |
| K6162_RS29145 | 8361..8573 | + | 213 | WP_021527181.1 | MbeD family mobilization/exclusion protein | - |
| K6162_RS29550 | 8949..9077 | - | 129 | WP_000523570.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | - | 1..11192 | 11192 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10342.96 Da Isoelectric Point: 9.8727
>T213940 WP_004197762.1 NZ_CP082017:3852-4118 [Klebsiella pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD
Download Length: 267 bp
>T213940 NZ_CP109924:686077-686391 [Escherichia coli O125ac:K+:H10]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 75 a.a. Molecular weight: 8369.28 Da Isoelectric Point: 4.6533
>AT213940 WP_000879771.1 NZ_CP082017:3644-3868 [Klebsiella pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD
Download Length: 225 bp
>AT213940 NZ_CP109924:686388-686804 [Escherichia coli O125ac:K+:H10]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCGGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCAAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCGGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCAAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|