213923

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3119168..3119822 Replicon chromosome
Accession NZ_CP082014
Organism Klebsiella pneumoniae strain KP18-238

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag K6162_RS15275 Protein ID WP_004144731.1
Coordinates 3119415..3119822 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K6162_RS15270 Protein ID WP_002916312.1
Coordinates 3119168..3119434 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6162_RS15245 3114324..3115757 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
K6162_RS15250 3115876..3116604 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K6162_RS15255 3116654..3116965 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
K6162_RS15260 3117129..3117788 + 660 WP_002916317.1 hemolysin III family protein -
K6162_RS15265 3117939..3118922 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
K6162_RS15270 3119168..3119434 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K6162_RS15275 3119415..3119822 + 408 WP_004144731.1 protein YgfX Toxin
K6162_RS15280 3119829..3120350 - 522 WP_002916308.1 flavodoxin FldB -
K6162_RS15285 3120451..3121347 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K6162_RS15290 3121370..3122083 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K6162_RS15295 3122089..3123822 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T213923 WP_004144731.1 NZ_CP082014:3119415-3119822 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T213923 NZ_CP109921:c821815-821438 [Escherichia coli O2:K2:H1]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT213923 WP_002916312.1 NZ_CP082014:3119168-3119434 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT213923 NZ_CP109921:c822272-821892 [Escherichia coli O2:K2:H1]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCGCCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References