Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2444600..2445239 Replicon chromosome
Accession NC_007650
Organism Burkholderia thailandensis E264

Toxin (Protein)


Gene name hicA Uniprot ID Q2T3Q6
Locus tag BTH_RS10220 Protein ID WP_009893919.1
Coordinates 2445060..2445239 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q2T3Q7
Locus tag BTH_RS10215 Protein ID WP_011401461.1
Coordinates 2444600..2445016 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTH_RS10205 2441696..2442430 + 735 WP_009893914.1 hypothetical protein -
BTH_RS30415 2442483..2443055 + 573 WP_009893915.1 site-specific integrase -
BTH_RS10210 2443674..2444171 + 498 WP_011401460.1 hypothetical protein -
BTH_RS10215 2444600..2445016 - 417 WP_011401461.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BTH_RS10220 2445060..2445239 - 180 WP_009893919.1 type II toxin-antitoxin system HicA family toxin Toxin
BTH_RS10225 2445519..2446046 + 528 WP_011401462.1 PAAR domain-containing protein -
BTH_RS10230 2446043..2446777 + 735 WP_011401463.1 VRR-NUC domain-containing protein -
BTH_RS10235 2446787..2447902 + 1116 WP_009893924.1 DUF3396 domain-containing protein -
BTH_RS10240 2447973..2448548 - 576 WP_009893925.1 recombinase family protein -
BTH_RS30425 2448870..2449850 - 981 WP_043037760.1 DUF3644 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2444600..2464170 19570


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6618.82 Da        Isoelectric Point: 11.2336

>T21390 WP_009893919.1 NC_007650:c2445239-2445060 [Burkholderia thailandensis E264]
MNSSKLIRMLEEDGWRLVRVTGSHHHFKHPKKPGLVTVPHPKKDLPIGTVKSIQKSAGL

Download         Length: 180 bp

>T21390 NC_007650:c2445239-2445060 [Burkholderia thailandensis E264]
ATGAACTCATCGAAGCTGATCCGGATGCTTGAGGAAGATGGCTGGAGGTTGGTTCGAGTGACAGGCAGCCATCATCATTT
CAAACACCCCAAGAAGCCAGGTCTTGTGACGGTTCCCCACCCGAAGAAGGACCTACCGATTGGGACTGTAAAAAGCATCC
AGAAATCCGCCGGCCTGTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15106.03 Da        Isoelectric Point: 4.6944

>AT21390 WP_011401461.1 NC_007650:c2445016-2444600 [Burkholderia thailandensis E264]
MEFPIAVHKDDGSVYGVTVPDIPGVHSWGETIDDAIKNTREAIVGHVETLIELGDDVEFTCSTVEELVAKPEYAGAVWAL
VSVDLSQLDSKPERINVSIPRFVLHKIDAYVASRHETRSGFLARAALEALNEGKVRHA

Download         Length: 417 bp

>AT21390 NC_007650:c2445016-2444600 [Burkholderia thailandensis E264]
ATGGAATTTCCCATCGCAGTGCATAAGGACGATGGGAGCGTCTACGGCGTGACGGTCCCGGATATTCCGGGCGTTCACTC
CTGGGGCGAAACCATCGATGATGCAATCAAAAACACGAGAGAGGCTATCGTCGGCCATGTAGAGACATTGATCGAGCTTG
GGGACGATGTTGAATTCACTTGCTCGACGGTGGAAGAACTGGTTGCAAAGCCCGAGTACGCCGGGGCGGTTTGGGCGCTC
GTCAGCGTTGATCTTTCTCAGCTTGATTCCAAGCCCGAGCGGATCAATGTGAGTATCCCTCGCTTCGTGCTGCACAAGAT
TGACGCCTATGTGGCATCCCGCCACGAGACTAGAAGCGGATTTCTTGCGCGTGCTGCCCTGGAGGCACTTAATGAAGGCA
AAGTTAGGCACGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4C26
PDB 6G26

Antitoxin

Source ID Structure
AlphaFold DB Q2T3Q7

References