Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4883419..4883935 Replicon chromosome
Accession NZ_CP082005
Organism Klebsiella pneumoniae strain KP18-8

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag K6148_RS24190 Protein ID WP_004178374.1
Coordinates 4883419..4883703 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K6148_RS24195 Protein ID WP_002886901.1
Coordinates 4883693..4883935 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6148_RS24165 (4878903) 4878903..4879166 - 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -
K6148_RS24170 (4879296) 4879296..4879469 + 174 WP_032408826.1 hypothetical protein -
K6148_RS24175 (4879472) 4879472..4880215 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
K6148_RS24180 (4880572) 4880572..4882710 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
K6148_RS24185 (4882951) 4882951..4883415 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K6148_RS24190 (4883419) 4883419..4883703 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6148_RS24195 (4883693) 4883693..4883935 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6148_RS24200 (4884013) 4884013..4885923 - 1911 WP_004178373.1 PRD domain-containing protein -
K6148_RS24205 (4885946) 4885946..4887100 - 1155 WP_004178372.1 lactonase family protein -
K6148_RS24210 (4887167) 4887167..4887907 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T213880 WP_004178374.1 NZ_CP082005:c4883703-4883419 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T213880 NZ_CP082005:c4883703-4883419 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT213880 WP_002886901.1 NZ_CP082005:c4883935-4883693 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT213880 NZ_CP082005:c4883935-4883693 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References