Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT_toxin-BrnA
Location 1216197..1216734 Replicon chromosome
Accession NC_007650
Organism Burkholderia thailandensis E264

Toxin (Protein)


Gene name brnT Uniprot ID Q2T6G2
Locus tag BTH_RS05365 Protein ID WP_004549731.1
Coordinates 1216197..1216466 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q2T6G1
Locus tag BTH_RS05370 Protein ID WP_011401115.1
Coordinates 1216450..1216734 (+) Length 95 a.a.

Genomic Context

BTH_RS05330BTH_RS05335BTH_RS05340BTH_RS05345BTH_RS05350BTH_RS29935BTH_RS05355BTH_RS05360BTH_RS05365BTH_RS05370BTH_RS05375BTH_RS05380BTH_RS05385BTH_RS05390
Location: 1211574..1212395 (822 bp)
Type: Others
Protein ID: WP_009896491.1
Location: 1212392..1212652 (261 bp)
Type: Others
Protein ID: WP_004526650.1
Location: 1212806..1213798 (993 bp)
Type: Others
Protein ID: WP_015967393.1
Location: 1213795..1214346 (552 bp)
Type: Others
Protein ID: WP_011401112.1
Location: 1214343..1214699 (357 bp)
Type: Others
Protein ID: WP_009896497.1
Location: 1215139..1215471 (333 bp)
Type: Others
Protein ID: WP_011401114.1
Location: 1215447..1215707 (261 bp)
Type: Others
Protein ID: WP_009896498.1
Location: 1215704..1216147 (444 bp)
Type: Others
Protein ID: WP_009896499.1
Location: 1216197..1216466 (270 bp)
Type: Toxin
Protein ID: WP_004549731.1
Location: 1216450..1216734 (285 bp)
Type: Antitoxin
Protein ID: WP_011401115.1
Location: 1217365..1217844 (480 bp)
Type: Others
Protein ID: WP_025404174.1
Location: 1217844..1219586 (1743 bp)
Type: Others
Protein ID: WP_011401117.1
Location: 1219594..1220889 (1296 bp)
Type: Others
Protein ID: WP_009896509.1
Location: 1220867..1221709 (843 bp)
Type: Others
Protein ID: WP_011401119.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BTH_RS053301211574..1212395+822WP_009896491.1hypothetical protein-
BTH_RS053351212392..1212652+261WP_004526650.1helix-turn-helix domain-containing protein-
BTH_RS053401212806..1213798+993WP_015967393.1hypothetical protein-
BTH_RS053451213795..1214346+552WP_011401112.1DUF1064 domain-containing protein-
BTH_RS053501214343..1214699+357WP_009896497.1hypothetical protein-
BTH_RS299351215139..1215471+333WP_011401114.1hypothetical protein-
BTH_RS053551215447..1215707+261WP_009896498.1hypothetical protein-
BTH_RS053601215704..1216147+444WP_009896499.1hypothetical protein-
BTH_RS053651216197..1216466+270WP_004549731.1BrnT family toxinToxin
BTH_RS053701216450..1216734+285WP_011401115.1BrnA antitoxin family proteinAntitoxin
BTH_RS053751217365..1217844+480WP_025404174.1terminase small subunit-
BTH_RS053801217844..1219586+1743WP_011401117.1terminase large subunit-
BTH_RS053851219594..1220889+1296WP_009896509.1phage portal protein-
BTH_RS053901220867..1221709+843WP_011401119.1Clp protease ClpP-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1194774..124140846634


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-81)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(27-88)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10157.46 Da        Isoelectric Point: 5.6831

>T21388 WP_004549731.1 NC_007650:1216197-1216466 [Burkholderia thailandensis E264]
MDITFDPTKNETNIAKHGVSLALAAQLDWSDVLSYVDDRRDYSEVREVGFGVIGDRLYCVVFTQRGDSMHIISMRKANKR
EVKSYVEQA

Download         Length: 270 bp

>T21388 NC_007650:1216197-1216466 [Burkholderia thailandensis E264]
ATGGACATCACCTTTGACCCGACCAAGAACGAAACGAACATTGCCAAGCATGGAGTGTCGTTGGCGCTTGCAGCGCAACT
CGACTGGTCGGACGTGTTGTCCTACGTGGACGACCGACGCGACTACAGTGAAGTGCGCGAAGTCGGGTTCGGTGTGATCG
GCGATCGCCTCTATTGCGTGGTGTTCACGCAGCGCGGCGACTCGATGCACATCATCAGCATGCGTAAGGCGAACAAGCGG
GAGGTCAAGAGCTATGTCGAGCAAGCGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10669.09 Da        Isoelectric Point: 5.8930

>AT21388 WP_011401115.1 NC_007650:1216450-1216734 [Burkholderia thailandensis E264]
MSSKRKIVMPTDEEDAAINRGIAADPDTFEVPAEDFAKMTRRGKRGRPPLEAPKVQLTVRYDVDIVDAFKATGEGWQTRM
NDALREWLKEHQPA

Download         Length: 285 bp

>AT21388 NC_007650:1216450-1216734 [Burkholderia thailandensis E264]
ATGTCGAGCAAGCGTAAGATCGTCATGCCGACGGACGAGGAAGACGCGGCAATCAACCGCGGCATCGCGGCCGATCCCGA
CACGTTCGAAGTGCCGGCGGAAGACTTCGCGAAGATGACGCGGCGAGGCAAGCGTGGTCGTCCGCCGCTCGAAGCGCCCA
AGGTGCAATTGACGGTGCGCTACGACGTCGACATCGTGGACGCCTTCAAGGCAACAGGCGAAGGTTGGCAGACGCGTATG
AATGATGCGTTGCGCGAGTGGCTGAAGGAGCACCAGCCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ2T6G2

Antitoxin

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Source
ID
Structure
AlphaFold DBQ2T6G1

References