Detailed information of TA system TA021387

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 6588292..6589329
• Replicon: chromosome
• Accession: NC_007645
• Organism: Hahella chejuensis KCTC 2396

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: HCH_RS29125
• Protein ID: WP_041599009.1
• Coordinates: 6588292..6588861 (-)
• Length: 190 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: Q2S8C6
• Locus tag: HCH_RS29130
• Protein ID: WP_011400150.1
• Coordinates: 6588865..6589329 (-)
• Length: 155 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HCH_RS29105	6583293..6585818	+	2526	WP_041599008.1	FtsX-like permease family protein	-
HCH_RS29110	6585815..6586495	-	681	WP_011400146.1	hypothetical protein	-
HCH_RS29115	6586492..6587427	-	936	WP_011400147.1	aldo/keto reductase	-
HCH_RS29120	6587538..6588152	-	615	WP_011400148.1	hypothetical protein	-
HCH_RS29125	6588292..6588861	-	570	WP_041599009.1	PIN domain-containing protein	Toxin
HCH_RS29130	6588865..6589329	-	465	WP_011400150.1	helix-turn-helix domain-containing protein	Antitoxin
HCH_RS29135	6589556..6590425	+	870	WP_011400151.1	hypothetical protein	-
HCH_RS29140	6590520..6592067	-	1548	WP_011400152.1	VCBS repeat-containing protein	-
HCH_RS29145	6592207..6593865	-	1659	WP_011400153.1	DUF3459 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-113)

Antitoxin

• Helix-turn-helix domain, group 17 (79-124)

Sequences

Toxin

Protein

• Length: 190 a.a.
• Molecular weight: 21683.21 Da
• Isoelectric Point: 4.9264

>T21387 WP_041599009.1 NC_007645:c6588861-6588292 [Hahella chejuensis KCTC 2396]
IMARYSVILDACVLYPAPLRDLFMRLAMEDLFMARWTDLIHEEWINALMRQGKFLREDLERIKCLMDSHVRDAKVTGFEG
LIESISLPDPDDRHVVAAAIRAGADAIVSFNLKDFPTNELEKYDLEVIHPDDFVCFQLELAPGAACQAIKQQREALKNPP
IDKEKFLAILQKQQLPQTVNILRQYTSLI

Nucleotide

• Length: 570 bp

>T21387 NC_007645:c6588861-6588292 [Hahella chejuensis KCTC 2396]
ATCATGGCTAGGTACTCTGTGATTCTTGATGCTTGCGTACTTTATCCTGCGCCTCTGAGAGACCTTTTTATGCGCTTGGC
GATGGAGGATCTATTTATGGCAAGGTGGACGGACCTTATTCATGAGGAATGGATTAATGCGCTGATGAGACAGGGGAAGT
TTTTGCGTGAGGACCTAGAGAGAATCAAGTGCTTGATGGATTCTCATGTTAGAGATGCAAAGGTCACAGGATTTGAGGGT
TTAATAGAGTCTATCAGTCTGCCAGACCCTGATGACAGACATGTTGTTGCAGCTGCTATTCGCGCCGGAGCTGATGCGAT
TGTTTCTTTTAATTTAAAGGATTTTCCAACAAACGAGCTTGAAAAGTACGACCTAGAGGTTATTCACCCTGATGACTTTG
TATGTTTTCAGTTGGAGTTAGCGCCTGGCGCAGCCTGTCAGGCAATCAAGCAGCAAAGGGAAGCTTTAAAAAATCCTCCA
ATTGATAAAGAAAAGTTTCTTGCAATTCTGCAAAAGCAACAGTTGCCACAAACGGTTAACATCCTGCGGCAATACACTTC
TCTGATATGA

Antitoxin

Protein

• Length: 155 a.a.
• Molecular weight: 17039.51 Da
• Isoelectric Point: 6.7234

>AT21387 WP_011400150.1 NC_007645:c6589329-6588865 [Hahella chejuensis KCTC 2396]
MASNVVQLPTAQDVEEAKRSSRALAKYASADRVQLSIKGSNNEKDEIVLPGPVVQLLLNILAEMSRGNAISIMPIHAELT
TQEAATFLNVSRPFFVKLLENHQLPFRKVGSHRRVLAKDVMDYKSSIDKQRCDSLDELAAVSQKLGMGYDLDSE

Nucleotide

• Length: 465 bp

>AT21387 NC_007645:c6589329-6588865 [Hahella chejuensis KCTC 2396]
ATGGCGTCTAACGTCGTTCAGTTGCCAACGGCCCAGGACGTAGAGGAAGCGAAGCGATCAAGCAGGGCATTGGCAAAGTA
CGCCTCAGCTGATCGTGTACAGCTCAGTATCAAAGGTAGTAACAACGAGAAAGATGAAATTGTTTTGCCTGGCCCTGTAG
TGCAATTGCTACTTAATATTCTGGCGGAAATGTCACGAGGAAATGCAATTAGCATCATGCCAATCCATGCGGAGTTAACA
ACTCAAGAGGCGGCTACCTTTCTCAACGTCAGCCGTCCATTTTTTGTGAAGTTACTTGAGAATCATCAGCTTCCGTTTCG
TAAAGTTGGGTCTCATAGGCGTGTTCTTGCAAAAGACGTAATGGACTATAAAAGCAGCATAGACAAGCAAAGGTGTGATT
CCCTCGATGAGTTAGCGGCGGTATCACAAAAATTAGGAATGGGGTACGACTTGGATTCGGAATAA

Structures

Antitoxin

• AlphaFold DB: Q2S8C6