Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 993815..994472 Replicon chromosome
Accession NZ_CP082005
Organism Klebsiella pneumoniae strain KP18-8

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag K6148_RS05655 Protein ID WP_002916310.1
Coordinates 994062..994472 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K6148_RS05650 Protein ID WP_002916312.1
Coordinates 993815..994081 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6148_RS05625 (988971) 988971..990404 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
K6148_RS05630 (990523) 990523..991251 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K6148_RS05635 (991301) 991301..991612 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
K6148_RS05640 (991776) 991776..992435 + 660 WP_002916317.1 hemolysin III family protein -
K6148_RS05645 (992586) 992586..993569 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
K6148_RS05650 (993815) 993815..994081 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K6148_RS05655 (994062) 994062..994472 + 411 WP_002916310.1 protein YgfX Toxin
K6148_RS05660 (994479) 994479..995000 - 522 WP_004144730.1 flavodoxin FldB -
K6148_RS05665 (995101) 995101..995997 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K6148_RS05670 (996020) 996020..996733 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K6148_RS05675 (996739) 996739..998472 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T213868 WP_002916310.1 NZ_CP082005:994062-994472 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T213868 NZ_CP109891:1161851-1162117 [Xylella fastidiosa subsp. fastidiosa]
TTGGCCTGGACGATTGATTACACCGACACGGCCAAGCAGCAGTTACGCAAGCTCGACAAGCACATGGCGCGGCGCATTGT
CGATTTCATGGATGAGCGCATCGCCGGACTAGAAAACCCACGCAGCAGTGGTAAAGCATTAACCGGACCACTTGGCGGCT
TTTGGCGTTATCGTGTTGGTGATTTCCGGGTCGTCTGCGCCATTCAAGATAGCGTTTTGCGCGTCCTTGTAGTGCGTGTT
GGTCACCGGGGTGAGATTTACCGATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT213868 WP_002916312.1 NZ_CP082005:993815-994081 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT213868 NZ_CP109891:1161640-1161867 [Xylella fastidiosa subsp. fastidiosa]
ATGGCGACTTCGATTCGCCTCTCTCCTGAAATGGAGCAAAGGCTGAACTCTCTTGCCTCCCATACGGGACGCACAAAGGC
TTACTACCTACGTGAAATCATTGAGCATGGCATTGAGGAAATGGAGGATTACTACCTTGCTGCCGATGTGTTGGAACGTG
TCCGTCATGGACAAGAACAGGTGCATTCTGCTGCCGATGTGAGGAAAACGCTTGGCCTGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References