Detailed information of TA system TA021386

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/GNAT-DUF1778
• Location: 5745280..5746073
• Replicon: chromosome
• Accession: NC_007645
• Organism: Hahella chejuensis KCTC 2396

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: HCH_RS25245
• Protein ID: WP_041599943.1
• Coordinates: 5745280..5745780 (-)
• Length: 167 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: Q2SAN8
• Locus tag: HCH_RS25250
• Protein ID: WP_011399348.1
• Coordinates: 5745795..5746073 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HCH_RS25210	5740886..5741206	+	321	WP_011399339.1	helix-turn-helix domain-containing protein	-
HCH_RS25215	5741400..5741816	-	417	WP_011399340.1	4-oxalocrotonate tautomerase	-
HCH_RS25220	5741937..5742581	+	645	WP_011399341.1	TetR/AcrR family transcriptional regulator	-
HCH_RS25230	5742996..5743487	+	492	WP_011399344.1	DUF2924 domain-containing protein	-
HCH_RS25235	5743484..5744839	+	1356	WP_011399345.1	recombinase family protein	-
HCH_RS25240	5744836..5745264	+	429	WP_011399346.1	hypothetical protein	-
HCH_RS25245	5745280..5745780	-	501	WP_041599943.1	GNAT family N-acetyltransferase	Toxin
HCH_RS25250	5745795..5746073	-	279	WP_011399348.1	DUF1778 domain-containing protein	Antitoxin
HCH_RS25255	5746438..5747580	-	1143	WP_011399350.1	hypothetical protein	-
HCH_RS25260	5747721..5748272	+	552	WP_011399351.1	DNA repair protein RadC	-
HCH_RS25265	5748622..5749146	+	525	WP_011399353.1	hypothetical protein	-
HCH_RS25270	5749500..5751041	+	1542	WP_011395130.1	IS21 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (42-146)

Antitoxin

• Vibrio phage ICP1, Orf50 (11-86)

Sequences

Toxin

Protein

• Length: 167 a.a.
• Molecular weight: 18453.25 Da
• Isoelectric Point: 7.2900

>T21386 WP_041599943.1 NC_007645:c5745780-5745280 [Hahella chejuensis KCTC 2396]
VSPYEPVRKLAATDQVDAFDCGQVALNQFLQRYAFVNQKANSAQTYVCRLGDLVVGFYSLAVGSVDPEAAPSRVMKGLAR
HPVPVMILARLAVDKEHQRQGLGQALLKDALLRTAQAADIAGIRCLLVHAKDDAARRWYESWEFEPSPTDPYHLFLMLKD
LKSLLD

Nucleotide

• Length: 501 bp

>T21386 NC_007645:c5745780-5745280 [Hahella chejuensis KCTC 2396]
GTGTCGCCCTACGAACCTGTTCGCAAACTTGCGGCAACGGATCAGGTCGATGCGTTCGACTGTGGCCAAGTCGCGCTGAA
CCAGTTCCTGCAGCGCTACGCGTTCGTCAACCAGAAGGCCAACAGCGCGCAGACCTACGTTTGCCGCCTGGGAGATCTGG
TGGTCGGCTTCTACAGCCTCGCCGTCGGAAGCGTCGACCCGGAAGCTGCGCCGTCGAGGGTGATGAAGGGACTGGCGCGC
CATCCGGTACCGGTCATGATCCTCGCCCGGCTCGCGGTGGATAAGGAACATCAGCGTCAGGGGCTAGGCCAGGCATTGCT
CAAGGATGCGCTGCTGCGCACAGCACAGGCCGCCGACATCGCTGGCATCCGTTGCCTGCTGGTGCATGCCAAGGACGATG
CGGCGCGGCGCTGGTACGAGTCCTGGGAATTTGAGCCCAGCCCGACCGATCCGTATCACCTGTTTCTAATGCTCAAGGAT
CTTAAGAGCTTGTTGGACTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10240.78 Da
• Isoelectric Point: 10.4779

>AT21386 WP_011399348.1 NC_007645:c5746073-5745795 [Hahella chejuensis KCTC 2396]
MSTPNVSKTERIDVRASTPVKQLLQEAARVCHKNVSEFLLDAGVTAATQTLADRRQFVLGEAQWQAFQEALDRPVQSKPR
LKKLLREPGVLG

Nucleotide

• Length: 279 bp

>AT21386 NC_007645:c5746073-5745795 [Hahella chejuensis KCTC 2396]
ATGAGCACCCCGAATGTTTCCAAGACCGAACGTATTGACGTCCGTGCAAGCACGCCGGTCAAGCAACTGCTACAGGAAGC
TGCACGCGTCTGCCACAAGAACGTCAGCGAGTTCCTGCTTGATGCGGGCGTGACGGCCGCCACGCAGACGCTGGCGGATC
GTCGCCAGTTCGTGCTGGGCGAGGCACAGTGGCAGGCTTTCCAGGAAGCGCTTGATCGTCCGGTGCAAAGCAAACCGCGT
CTGAAGAAGCTGCTGCGTGAGCCCGGGGTGCTGGGTTGA

Structures

Antitoxin

• AlphaFold DB: Q2SAN8