Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 4925352..4925868 | Replicon | chromosome |
Accession | NZ_CP082001 | ||
Organism | Klebsiella pneumoniae strain KP18-1 |
Toxin (Protein)
Gene name | relE | Uniprot ID | J2XDK6 |
Locus tag | K6149_RS24345 | Protein ID | WP_002886902.1 |
Coordinates | 4925352..4925636 (-) | Length | 95 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | R4Y888 |
Locus tag | K6149_RS24350 | Protein ID | WP_002886901.1 |
Coordinates | 4925626..4925868 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K6149_RS24320 | 4920836..4921099 | - | 264 | WP_004152271.1 | PTS sugar transporter subunit IIB | - |
K6149_RS24325 | 4921229..4921402 | + | 174 | WP_002886906.1 | hypothetical protein | - |
K6149_RS24330 | 4921405..4922148 | + | 744 | WP_002886905.1 | MurR/RpiR family transcriptional regulator | - |
K6149_RS24335 | 4922505..4924643 | + | 2139 | WP_002886904.1 | anaerobic ribonucleoside-triphosphate reductase | - |
K6149_RS24340 | 4924884..4925348 | + | 465 | WP_002886903.1 | anaerobic ribonucleoside-triphosphate reductase-activating protein | - |
K6149_RS24345 | 4925352..4925636 | - | 285 | WP_002886902.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
K6149_RS24350 | 4925626..4925868 | - | 243 | WP_002886901.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
K6149_RS24355 | 4925946..4927856 | - | 1911 | WP_004152270.1 | PRD domain-containing protein | - |
K6149_RS24360 | 4927879..4929033 | - | 1155 | WP_002886900.1 | lactonase family protein | - |
K6149_RS24365 | 4929099..4929839 | - | 741 | WP_002886899.1 | KDGP aldolase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11125.95 Da Isoelectric Point: 10.3787
>T213850 WP_002886902.1 NZ_CP082001:c4925636-4925352 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
Download Length: 285 bp
>T213850 NZ_CP109889:22415-22858 [Xylella fastidiosa subsp. fastidiosa]
ATGATGTATGTTCTTGATACCAACGTGGTGTCAGAGCTGCGAAAAATTCAGGTGGGTAAGGCTGACTCAAACGTTGCGGC
ATGGACTCAAAGCGTCGATGCCTCAGAACTCTTCGTGTCCGCTATCACTATTATGGAATTGGAGTTGGGCGTTTTGTCGA
TTGAGCGCAAGGACATTACCCAAGGGACATTGTTGCGTATATGGATGGAGCAACACGTATTGCCGGAATTTTCAGAGAGA
ACATTGCCCGTCGATACAGTCGTGGCACTGCGTTGCGCTCAGCTGCACGTTCCCGACAGGTGCGACGAGCGTGACGCACT
CATTGCAGCAACGGCGCTTGTGCATGGTATGGCAGTCGTTACTCGCAACGTGGCTGATTTCCAGCCGACAGGAGTGACCA
TCCTGAATCCGTGGGAGTGGCGCAGTCATACCTGCTCAGAGTGA
ATGATGTATGTTCTTGATACCAACGTGGTGTCAGAGCTGCGAAAAATTCAGGTGGGTAAGGCTGACTCAAACGTTGCGGC
ATGGACTCAAAGCGTCGATGCCTCAGAACTCTTCGTGTCCGCTATCACTATTATGGAATTGGAGTTGGGCGTTTTGTCGA
TTGAGCGCAAGGACATTACCCAAGGGACATTGTTGCGTATATGGATGGAGCAACACGTATTGCCGGAATTTTCAGAGAGA
ACATTGCCCGTCGATACAGTCGTGGCACTGCGTTGCGCTCAGCTGCACGTTCCCGACAGGTGCGACGAGCGTGACGCACT
CATTGCAGCAACGGCGCTTGTGCATGGTATGGCAGTCGTTACTCGCAACGTGGCTGATTTCCAGCCGACAGGAGTGACCA
TCCTGAATCCGTGGGAGTGGCGCAGTCATACCTGCTCAGAGTGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9045.55 Da Isoelectric Point: 6.3340
>AT213850 WP_002886901.1 NZ_CP082001:c4925868-4925626 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL
Download Length: 243 bp
>AT213850 NZ_CP109889:22918-23241 [Xylella fastidiosa subsp. fastidiosa]
ATGATCGAAATTGAAGAAGGTAGCGGCAACGTCTATGCCGATCTTGTCATTCTTGACGCCGACGAAATGCTGGTGAAGGC
GCAGCTTGCTACGAAGATCGGCGAGATCATCAAGGGTCGCGGATGGACTCAGCAGGAAGTTGCCGACGTGCTCGGCATGA
CACAACCCAAGCTGTCGAAGATGCTGCTCGGACAGTTCCGAGGTATCAGCGAAGCGAAGATGCTGGAATGCCTTGCGCAG
CTCGGTTGGCAAGTTCAGATCGTCGTCGGTCCCGCTTGCCTTACAAACGACGCGGGTCACGTCGAAGTCGCATTCGTGGC
CTAA
ATGATCGAAATTGAAGAAGGTAGCGGCAACGTCTATGCCGATCTTGTCATTCTTGACGCCGACGAAATGCTGGTGAAGGC
GCAGCTTGCTACGAAGATCGGCGAGATCATCAAGGGTCGCGGATGGACTCAGCAGGAAGTTGCCGACGTGCTCGGCATGA
CACAACCCAAGCTGTCGAAGATGCTGCTCGGACAGTTCCGAGGTATCAGCGAAGCGAAGATGCTGGAATGCCTTGCGCAG
CTCGGTTGGCAAGTTCAGATCGTCGTCGGTCCCGCTTGCCTTACAAACGACGCGGGTCACGTCGAAGTCGCATTCGTGGC
CTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GMH2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GLP0 |