Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4925352..4925868 Replicon chromosome
Accession NZ_CP082001
Organism Klebsiella pneumoniae strain KP18-1

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag K6149_RS24345 Protein ID WP_002886902.1
Coordinates 4925352..4925636 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K6149_RS24350 Protein ID WP_002886901.1
Coordinates 4925626..4925868 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6149_RS24320 4920836..4921099 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
K6149_RS24325 4921229..4921402 + 174 WP_002886906.1 hypothetical protein -
K6149_RS24330 4921405..4922148 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
K6149_RS24335 4922505..4924643 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
K6149_RS24340 4924884..4925348 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K6149_RS24345 4925352..4925636 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6149_RS24350 4925626..4925868 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6149_RS24355 4925946..4927856 - 1911 WP_004152270.1 PRD domain-containing protein -
K6149_RS24360 4927879..4929033 - 1155 WP_002886900.1 lactonase family protein -
K6149_RS24365 4929099..4929839 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T213850 WP_002886902.1 NZ_CP082001:c4925636-4925352 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T213850 NZ_CP109889:22415-22858 [Xylella fastidiosa subsp. fastidiosa]
ATGATGTATGTTCTTGATACCAACGTGGTGTCAGAGCTGCGAAAAATTCAGGTGGGTAAGGCTGACTCAAACGTTGCGGC
ATGGACTCAAAGCGTCGATGCCTCAGAACTCTTCGTGTCCGCTATCACTATTATGGAATTGGAGTTGGGCGTTTTGTCGA
TTGAGCGCAAGGACATTACCCAAGGGACATTGTTGCGTATATGGATGGAGCAACACGTATTGCCGGAATTTTCAGAGAGA
ACATTGCCCGTCGATACAGTCGTGGCACTGCGTTGCGCTCAGCTGCACGTTCCCGACAGGTGCGACGAGCGTGACGCACT
CATTGCAGCAACGGCGCTTGTGCATGGTATGGCAGTCGTTACTCGCAACGTGGCTGATTTCCAGCCGACAGGAGTGACCA
TCCTGAATCCGTGGGAGTGGCGCAGTCATACCTGCTCAGAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT213850 WP_002886901.1 NZ_CP082001:c4925868-4925626 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT213850 NZ_CP109889:22918-23241 [Xylella fastidiosa subsp. fastidiosa]
ATGATCGAAATTGAAGAAGGTAGCGGCAACGTCTATGCCGATCTTGTCATTCTTGACGCCGACGAAATGCTGGTGAAGGC
GCAGCTTGCTACGAAGATCGGCGAGATCATCAAGGGTCGCGGATGGACTCAGCAGGAAGTTGCCGACGTGCTCGGCATGA
CACAACCCAAGCTGTCGAAGATGCTGCTCGGACAGTTCCGAGGTATCAGCGAAGCGAAGATGCTGGAATGCCTTGCGCAG
CTCGGTTGGCAAGTTCAGATCGTCGTCGGTCCCGCTTGCCTTACAAACGACGCGGGTCACGTCGAAGTCGCATTCGTGGC
CTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References