Detailed information of TA system TA021385

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prpT-prpA/CC2985(antitoxin)
• Location: 4681427..4681967
• Replicon: chromosome
• Accession: NC_007645
• Organism: Hahella chejuensis KCTC 2396

Toxin (Protein)

• Gene name: PrpT
• Uniprot ID: -
• Locus tag: HCH_RS20390
• Protein ID: WP_011398327.1
• Coordinates: 4681427..4681723 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: PrpA
• Uniprot ID: Q2SDL3
• Locus tag: HCH_RS20395
• Protein ID: WP_011398328.1
• Coordinates: 4681713..4681967 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HCH_RS20365	4676757..4677965	-	1209	WP_011398322.1	phage portal protein	-
HCH_RS20370	4677965..4679683	-	1719	WP_011398323.1	terminase large subunit	-
HCH_RS20375	4679698..4680174	-	477	WP_011398324.1	phage terminase small subunit P27 family	-
HCH_RS20380	4680321..4680608	-	288	WP_011398325.1	hypothetical protein	-
HCH_RS20385	4680749..4681411	-	663	WP_011398326.1	hypothetical protein	-
HCH_RS20390	4681427..4681723	-	297	WP_011398327.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HCH_RS20395	4681713..4681967	-	255	WP_011398328.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
HCH_RS33230	4682027..4682128	-	102	WP_083769802.1	HNH endonuclease	-
HCH_RS20405	4682214..4682714	+	501	WP_011398329.1	GNAT family N-acetyltransferase	-
HCH_RS33235	4682730..4683086	-	357	WP_011398330.1	HNH endonuclease	-
HCH_RS20415	4683086..4683364	-	279	WP_011398331.1	hypothetical protein	-
HCH_RS20420	4683364..4683768	-	405	WP_041598831.1	hypothetical protein	-
HCH_RS20425	4683765..4684157	-	393	WP_041598832.1	M15 family metallopeptidase	-
HCH_RS20430	4684237..4685625	-	1389	WP_011395787.1	group II intron reverse transcriptase/maturase	-
HCH_RS20435	4686268..4686738	-	471	WP_148212635.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4670604..4692487	21883

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-94)

Antitoxin

• Antitoxin ParD (13-80)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11361.01 Da
• Isoelectric Point: 9.5439

>T21385 WP_011398327.1 NC_007645:c4681723-4681427 [Hahella chejuensis KCTC 2396]
MTDNTFKLRPKAEADLVSIYQFSLREWGADKAEAYIREINEAFLTLVNNKTLGSDRSYVRPSLRAYYVGSHVVFYKPTVY
GVAVIRVLHQSMDYVRHL

Nucleotide

• Length: 297 bp

>T21385 NC_007645:c4681723-4681427 [Hahella chejuensis KCTC 2396]
ATGACGGATAACACATTCAAGCTTCGTCCTAAAGCGGAGGCTGATCTAGTCTCAATCTATCAGTTCTCGTTAAGGGAGTG
GGGAGCAGACAAGGCGGAAGCCTATATCAGGGAGATTAACGAAGCTTTCCTAACGCTCGTTAACAACAAGACTCTTGGCA
GTGATCGCAGCTACGTACGCCCTTCTTTGCGAGCTTATTACGTAGGCTCTCATGTAGTCTTCTACAAACCAACTGTTTAT
GGTGTCGCCGTTATTCGGGTTTTGCATCAGTCGATGGATTATGTGCGGCACTTATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9438.60 Da
• Isoelectric Point: 4.4297

>AT21385 WP_011398328.1 NC_007645:c4681967-4681713 [Hahella chejuensis KCTC 2396]
MPRTITFQPSAELESFISSMIETGSYNNQSEVIRAGLRLLQEQMAASKLQELRSLIDEGEASGELKNWDVNEFLARMKKT
SNDG

Nucleotide

• Length: 255 bp

>AT21385 NC_007645:c4681967-4681713 [Hahella chejuensis KCTC 2396]
ATGCCTAGAACAATCACCTTTCAGCCTAGCGCTGAGCTGGAAAGCTTCATTTCTTCGATGATCGAGACCGGCAGCTATAA
CAATCAGAGCGAAGTTATCCGAGCAGGGTTGAGGTTGCTACAAGAGCAGATGGCGGCTTCTAAACTGCAAGAGCTTCGTA
GCCTGATTGATGAGGGAGAAGCCAGCGGAGAGCTTAAAAACTGGGATGTGAATGAGTTTCTTGCAAGGATGAAAAAGACC
TCGAATGACGGATAA

Structures

Antitoxin

• AlphaFold DB: Q2SDL3