Detailed information of TA system TA213847

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2800905..2802493
• Replicon: chromosome
• Accession: NZ_CP082001
• Organism: Klebsiella pneumoniae strain KP18-1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A0H3GN97
• Locus tag: K6149_RS13960
• Protein ID: WP_004199851.1
• Coordinates: 2800905..2802227 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: K6149_RS13965
• Protein ID: WP_002904790.1
• Coordinates: 2802227..2802493 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6149_RS13945	2795970..2798471	+	2502	WP_004199853.1	fimbria/pilus outer membrane usher protein	-
K6149_RS13950	2798459..2799463	+	1005	WP_004199852.1	fimbrial protein	-
K6149_RS13955	2799596..2800888	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
K6149_RS13960	2800905..2802227	-	1323	WP_004199851.1	type II toxin-antitoxin system HipA family toxin	Toxin
K6149_RS13965	2802227..2802493	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
K6149_RS13970	2802759..2803085	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
K6149_RS13975	2803082..2803582	-	501	WP_002904787.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
K6149_RS13980	2803560..2804939	-	1380	WP_004199850.1	nucleobase:cation symporter-2 family protein	-
K6149_RS13985	2805285..2806439	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
K6149_RS13990	2806420..2807343	-	924	WP_004199849.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49128.44 Da
• Isoelectric Point: 7.2487

>T213847 WP_004199851.1 NZ_CP082001:c2802227-2800905 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T213847 NZ_CP109887:c2728-2447 [Xylella fastidiosa subsp. fastidiosa]
ATGCGGATGATTGACCGCGCATCAGCTTTTAAACGTGATTACAAGCGTGAGGCGAAAGGGCAGCGCCGGGCCACGCTCGA
TAACGATCTAAGGCCCGTTCTTGTGGCGCTGGCGACTGACCAGCCACTTGATGCTAAATACCGTGACCATGACCTGAGCG
GCGATTGGGCAGGCTACCGTGAATGTCACGTCAAGCCTGACTTGCTGCTGATCTACCGCAAGTCTGATGCCGACACACTC
AGACTTGCGCGGCTTGGCTCGCACAGCGAGCTTTTCGGTTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT213847 WP_002904790.1 NZ_CP082001:c2802493-2802227 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT213847 NZ_CP109887:c2981-2715 [Xylella fastidiosa subsp. fastidiosa]
ATGAGCACCACCGATACCTATGTACGCGCCCGCATTGATACCAACACCAAGGAGCGTGCCGCTGACGCGCTCGAAGCAAT
GGGACTGTCTATCTCGGATGCCATTCGTTTGCTGATGCTGCGCGTAGCTGATGAGCGCCGCTTGCCGTTCGATGTGAAGG
TGCCCAACACCACCACACGCAACGCCATTGCCGAGCTAGAGGCAGGCAAGGGCAGGCGGTTCGCTAATGTCGATGACTTG
ATGGCCGACCTGCATGCGGATGATTGA

Structures

Toxin

• AlphaFold DB: A0A0H3GN97

Antitoxin

• AlphaFold DB: A0A0H3GXD8