Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/CC2985(antitoxin)
Location 1438039..1438586 Replicon plasmid pZ25
Accession NZ_CP081988
Organism Shinella oryzae strain Z-25

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag K6301_RS22885 Protein ID WP_247221135.1
Coordinates 1438293..1438586 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag K6301_RS22880 Protein ID WP_247221134.1
Coordinates 1438039..1438293 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6301_RS22850 (K6301_22825) 1433554..1434642 - 1089 WP_247221131.1 GSU2403 family nucleotidyltransferase fold protein -
K6301_RS22855 (K6301_22830) 1435074..1435454 + 381 WP_247221132.1 DUF4440 domain-containing protein -
K6301_RS22860 (K6301_22835) 1435717..1436349 + 633 WP_247221133.1 DUF433 domain-containing protein -
K6301_RS22865 (K6301_22840) 1436346..1436726 + 381 Protein_1329 DUF5615 family PIN-like protein -
K6301_RS22870 (K6301_22845) 1436971..1437285 + 315 Protein_1330 integrase core domain-containing protein -
K6301_RS22875 1437386..1437650 - 265 Protein_1331 Fic family protein -
K6301_RS22880 (K6301_22850) 1438039..1438293 + 255 WP_247221134.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
K6301_RS22885 (K6301_22855) 1438293..1438586 + 294 WP_247221135.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6301_RS22890 (K6301_22860) 1438887..1439906 + 1020 WP_247221136.1 ABC transporter ATP-binding protein -
K6301_RS22895 (K6301_22865) 1439899..1440894 + 996 WP_247221137.1 ABC transporter ATP-binding protein -
K6301_RS22900 (K6301_22870) 1440905..1442524 + 1620 WP_247221138.1 dihydroxyacetone kinase subunit DhaK -
K6301_RS22905 (K6301_22875) 1443104..1443544 - 441 WP_247221139.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - adeG 1..1888955 1888955


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(6-71)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11244.94 Da        Isoelectric Point: 6.2174

>T213832 WP_247221135.1 NZ_CP081988:1438293-1438586 [Shinella oryzae]
MPFILSVQAEEDVISIAEEGIRIFGALVAKRYHDELFDLLELIASNPRMARERHEISPPVRIHPFKAHLVVYRIKEDGSV
FVIRIRHSHEDWATDSL

Download         Length: 294 bp

>T213832 NZ_CP109875:c6824-6549 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGTCGCGGTTATTTGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAAATTAATGGCCAGACTATTTAT
GTATTGCGTCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9398.46 Da        Isoelectric Point: 8.5775

>AT213832 WP_247221134.1 NZ_CP081988:1438039-1438293 [Shinella oryzae]
MATMNVSLPDPMKDWVEAQTKTGRYSNASDYVRDLIRRDQARTDKIAEMQRFVDDGIRSGVGSRSADDLFTAATTRAEIS
RGRA

Download         Length: 255 bp

>AT213832 NZ_CP109875:c7108-6824 [Escherichia coli]
ATGCAAATGAAAAACAATGCCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGTTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
TCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References