Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1411929..1412599 Replicon plasmid pZ25
Accession NZ_CP081988
Organism Shinella oryzae strain Z-25

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K6301_RS22755 Protein ID WP_247221116.1
Coordinates 1412180..1412599 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K6301_RS22750 Protein ID WP_247221115.1
Coordinates 1411929..1412183 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6301_RS22735 (K6301_22710) 1408115..1409827 + 1713 WP_247221112.1 iron ABC transporter permease -
K6301_RS22740 (K6301_22715) 1409845..1410945 + 1101 WP_247221113.1 ABC transporter ATP-binding protein -
K6301_RS22745 (K6301_22720) 1411002..1411661 + 660 WP_247221114.1 histidine phosphatase family protein -
K6301_RS22750 (K6301_22725) 1411929..1412183 + 255 WP_247221115.1 plasmid stabilization protein Antitoxin
K6301_RS22755 (K6301_22730) 1412180..1412599 + 420 WP_247221116.1 type II toxin-antitoxin system VapC family toxin Toxin
K6301_RS22760 (K6301_22735) 1412757..1413278 - 522 WP_247221117.1 GNAT family N-acetyltransferase -
K6301_RS22765 (K6301_22740) 1413464..1414495 - 1032 WP_247221118.1 LacI family DNA-binding transcriptional regulator -
K6301_RS22770 (K6301_22745) 1414747..1416000 + 1254 WP_247222492.1 sugar ABC transporter substrate-binding protein -
K6301_RS22775 (K6301_22750) 1416070..1416945 + 876 WP_247221119.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - adeG 1..1888955 1888955


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15023.35 Da        Isoelectric Point: 5.1532

>T213831 WP_247221116.1 NZ_CP081988:1412180-1412599 [Shinella oryzae]
MILLDTNLISEPWKPVPDQAVIAWLDAQAIETLFLSAITIAELRFGIAAMPLGKRQTVLRDRLEGEVLPHFSERILSFDL
AASQSYSELMARARISGKAIGTADGYIAATAAANGLAIATRDTRPFEAAGIKVINPWST

Download         Length: 420 bp

>T213831 NZ_CP109874:c4952706-4952395 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9444.68 Da        Isoelectric Point: 6.8813

>AT213831 WP_247221115.1 NZ_CP081988:1411929-1412183 [Shinella oryzae]
MPAVTIRNLSDETHRALRVRAAHHGRSTEAEIRDIIEAAVRPHQRVKLGSLLTAIGREAELYDSDIEALQKSRDKTPAEP
MTFE

Download         Length: 255 bp

>AT213831 NZ_CP109874:c4952394-4952104 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References