Detailed information of TA system TA021383

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 3684708..3685364
• Replicon: chromosome
• Accession: NC_007643
• Organism: Rhodospirillum rubrum ATCC 11170

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: RRU_RS16495
• Protein ID: WP_011390946.1
• Coordinates: 3685083..3685364 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q2RPF3
• Locus tag: RRU_RS16490
• Protein ID: WP_011390945.1
• Coordinates: 3684708..3685028 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RRU_RS16460	3680265..3681563	+	1299	WP_011390939.1	dihydroorotase	-
RRU_RS16465	3681556..3682206	+	651	WP_011390940.1	glycerol-3-phosphate 1-O-acyltransferase PlsY	-
RRU_RS16470	3682303..3682971	+	669	WP_011390941.1	glutathione S-transferase family protein	-
RRU_RS16475	3682974..3684098	+	1125	WP_011390942.1	DNA-processing protein DprA	-
RRU_RS16480	3684195..3684419	+	225	WP_011390943.1	TraY domain-containing protein	-
RRU_RS16485	3684403..3684672	+	270	WP_011390944.1	type II toxin-antitoxin system RelE/ParE family toxin	-
RRU_RS16490	3684708..3685028	-	321	WP_011390945.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
RRU_RS16495	3685083..3685364	-	282	WP_011390946.1	type II toxin-antitoxin system HicA family toxin	Toxin
RRU_RS16500	3685626..3686633	+	1008	WP_014626531.1	ABC transporter substrate-binding protein	-
RRU_RS16505	3686649..3688373	+	1725	WP_011390948.1	iron ABC transporter permease	-
RRU_RS16510	3688361..3689440	+	1080	WP_011390949.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (29-84)

Antitoxin

• Uncharacterised protein family HicB (52-101)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10114.69 Da
• Isoelectric Point: 10.8992

>T21383 WP_011390946.1 NC_007643:c3685364-3685083 [Rhodospirillum rubrum ATCC 11170]
MKSKGDLNSAHLKTLSAIFKNPASSTIVWMDIERLFLALGGTVDDSREGSRVAVSLNGIRAVFHRPHPRPCTEKGALRSV
RRFLVAAGIVEEG

Nucleotide

• Length: 282 bp

>T21383 NC_007643:c3685364-3685083 [Rhodospirillum rubrum ATCC 11170]
ATGAAATCAAAAGGTGATCTCAATTCCGCTCACCTGAAGACGCTTTCTGCGATATTTAAGAATCCCGCTTCTTCAACGAT
CGTTTGGATGGATATCGAGCGGTTGTTCCTGGCTCTGGGTGGAACTGTCGACGATAGCCGAGAAGGTAGTCGGGTTGCTG
TCTCTTTGAATGGAATCAGGGCTGTTTTTCATCGCCCCCACCCCAGGCCATGTACCGAGAAAGGGGCCCTGCGGTCGGTT
CGTCGATTTCTTGTCGCCGCCGGTATTGTCGAAGAAGGGTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11899.32 Da
• Isoelectric Point: 4.9044

>AT21383 WP_011390945.1 NC_007643:c3685028-3684708 [Rhodospirillum rubrum ATCC 11170]
MKYKGYTSSAIDFDEEDKLFSGTIDGIKDVVHFAASSADDLVQAFHDSVDDYLTYCQERGEEPDKPFNGRILLRTSPELH
RKAAMVAAREGLSLSKWLSRIIDRAA

Nucleotide

• Length: 321 bp

>AT21383 NC_007643:c3685028-3684708 [Rhodospirillum rubrum ATCC 11170]
ATGAAGTACAAGGGGTATACATCCAGCGCTATCGACTTCGATGAAGAAGACAAGCTGTTTTCTGGCACGATCGACGGGAT
CAAGGATGTCGTCCATTTCGCGGCCTCTTCGGCCGATGATCTTGTGCAGGCTTTTCACGATAGCGTTGACGACTATCTCA
CCTACTGCCAGGAACGGGGAGAAGAGCCCGATAAGCCGTTCAATGGCCGTATTCTGCTAAGAACATCTCCCGAATTGCAC
AGAAAAGCGGCGATGGTCGCCGCGCGTGAAGGGCTTAGCTTGTCGAAATGGCTTTCCCGGATCATCGACCGGGCCGCTTA
G

Structures

Antitoxin

• AlphaFold DB: Q2RPF3