Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 2082941..2083532 Replicon chromosome
Accession NZ_CP081987
Organism Shinella oryzae strain Z-25

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag K6301_RS10245 Protein ID WP_247216634.1
Coordinates 2082941..2083240 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag K6301_RS10250 Protein ID WP_247216636.1
Coordinates 2083242..2083532 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6301_RS10230 (K6301_10225) 2078822..2080090 - 1269 WP_247216630.1 cytochrome b N-terminal domain-containing protein -
K6301_RS10235 (K6301_10230) 2080105..2080683 - 579 WP_134647031.1 ubiquinol-cytochrome c reductase iron-sulfur subunit -
K6301_RS10240 (K6301_10235) 2080949..2082817 - 1869 WP_247216632.1 ABC transporter ATP-binding protein -
K6301_RS10245 (K6301_10240) 2082941..2083240 + 300 WP_247216634.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6301_RS10250 (K6301_10245) 2083242..2083532 + 291 WP_247216636.1 putative addiction module antidote protein Antitoxin
K6301_RS10255 (K6301_10250) 2083567..2085423 - 1857 WP_247216638.1 ABC transporter ATP-binding protein -
K6301_RS10260 (K6301_10255) 2085853..2086314 + 462 WP_247216640.1 tRNA (cytidine(34)-2'-O)-methyltransferase -
K6301_RS10265 (K6301_10260) 2086427..2086999 - 573 WP_247216642.1 NAD(P)H-dependent oxidoreductase -
K6301_RS10270 (K6301_10265) 2087070..2087540 + 471 WP_247216644.1 redox-sensitive transcriptional activator SoxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(5-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 10923.61 Da        Isoelectric Point: 10.3887

>T213828 WP_247216634.1 NZ_CP081987:2082941-2083240 [Shinella oryzae]
MALQIKQTETFRNWEQALGDRKARALIAARLTRIAYGLLGDVKSLGDGVSEIRIHHGPGYRIYFTRRGNEIIVLLCGGDK
GSQKRDIAAAKTLAAKLDD

Download         Length: 300 bp

>T213828 NZ_CP109874:4598711-4599085 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10354.70 Da        Isoelectric Point: 4.8096

>AT213828 WP_247216636.1 NZ_CP081987:2083242-2083532 [Shinella oryzae]
MNETLRNYDPAEALTSDEAVDVFMKDAFETRDAGYIAHALGVVARARGMSKVAEETGLAREALYRSLASDGNPTLKSMLT
VMQALGLELTSKRSGT

Download         Length: 291 bp

>AT213828 NZ_CP109874:4598253-4598621 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGTGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGTCTGACCTGCAAAGCTGACACCCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References