Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 3842442..3843484 | Replicon | chromosome |
| Accession | NZ_CP081966 | ||
| Organism | Pseudomonas mosselii strain DSM 17497 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | K5H97_RS17780 | Protein ID | WP_003153636.1 |
| Coordinates | 3842442..3843017 (-) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | I3TV68 |
| Locus tag | K5H97_RS17785 | Protein ID | WP_003050245.1 |
| Coordinates | 3843014..3843484 (-) | Length | 157 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K5H97_RS17755 (K5H97_17755) | 3838880..3839605 | - | 726 | WP_003050273.1 | CBASS effector endonuclease NucC | - |
| K5H97_RS17760 (K5H97_17760) | 3839644..3840546 | - | 903 | WP_003153640.1 | CBASS oligonucleotide cyclase | - |
| K5H97_RS17765 (K5H97_17765) | 3840546..3841046 | - | 501 | WP_003090159.1 | type III CBASS phage resistance system CD-NTase-associated protein Cap7 | - |
| K5H97_RS17770 (K5H97_17770) | 3841043..3841513 | - | 471 | WP_003153638.1 | type III CBASS phage resistance system CD-NTase-associated protein Cap8 | - |
| K5H97_RS17775 (K5H97_17775) | 3841510..3842424 | - | 915 | WP_003050256.1 | AAA family ATPase | - |
| K5H97_RS17780 (K5H97_17780) | 3842442..3843017 | - | 576 | WP_003153636.1 | PIN domain-containing protein | Toxin |
| K5H97_RS17785 (K5H97_17785) | 3843014..3843484 | - | 471 | WP_003050245.1 | helix-turn-helix domain-containing protein | Antitoxin |
| K5H97_RS17790 (K5H97_17790) | 3843688..3844071 | + | 384 | WP_003090167.1 | RAQPRD family integrative conjugative element protein | - |
| K5H97_RS17795 (K5H97_17795) | 3844068..3844301 | + | 234 | WP_003050225.1 | TIGR03758 family integrating conjugative element protein | - |
| K5H97_RS17800 (K5H97_17800) | 3844318..3844677 | + | 360 | WP_003153634.1 | TIGR03745 family integrating conjugative element membrane protein | - |
| K5H97_RS17805 (K5H97_17805) | 3844690..3845088 | + | 399 | WP_003153632.1 | TIGR03750 family conjugal transfer protein | - |
| K5H97_RS17810 (K5H97_17810) | 3845085..3845777 | + | 693 | WP_004350603.1 | TIGR03746 family integrating conjugative element protein | - |
| K5H97_RS17815 (K5H97_17815) | 3845774..3846685 | + | 912 | WP_004350604.1 | TIGR03749 family integrating conjugative element protein | - |
| K5H97_RS17820 (K5H97_17820) | 3846675..3848093 | + | 1419 | WP_004350605.1 | TIGR03752 family integrating conjugative element protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 3792914..3897884 | 104970 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21629.78 Da Isoelectric Point: 5.9995
>T213825 WP_003153636.1 NZ_CP081966:c3843017-3842442 [Pseudomonas mosselii]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
Download Length: 576 bp
>T213825 NZ_CP109874:c4161569-4161255 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAATC
CAATCCTTTTACTGGTAGATGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCACACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAATC
CAATCCTTTTACTGGTAGATGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCACACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
Antitoxin
Download Length: 157 a.a. Molecular weight: 17245.62 Da Isoelectric Point: 6.3803
>AT213825 WP_003050245.1 NZ_CP081966:c3843484-3843014 [Pseudomonas mosselii]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
Download Length: 471 bp
>AT213825 NZ_CP109874:c4161805-4161572 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACA
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACA
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|