Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 6462253..6462869 Replicon chromosome
Accession NZ_CP081943
Organism Pseudomonas sp. MM213

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag K5R88_RS29445 Protein ID WP_081501757.1
Coordinates 6462253..6462465 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag K5R88_RS29450 Protein ID WP_192226071.1
Coordinates 6462465..6462869 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5R88_RS29410 (K5R88_29290) 6457678..6458151 + 474 WP_192226062.1 cytochrome c-type biogenesis protein CcmH -
K5R88_RS29415 (K5R88_29295) 6458144..6459346 + 1203 WP_008039841.1 c-type cytochrome biogenesis protein CcmI -
K5R88_RS29420 (K5R88_29300) 6459361..6459765 + 405 WP_008039842.1 hypothetical protein -
K5R88_RS29425 (K5R88_29305) 6459822..6460397 - 576 WP_226298829.1 PIN domain-containing protein -
K5R88_RS29430 (K5R88_29310) 6460394..6460861 - 468 WP_223449629.1 helix-turn-helix domain-containing protein -
K5R88_RS29435 (K5R88_29315) 6460943..6461212 - 270 Protein_5802 LysR substrate-binding domain-containing protein -
K5R88_RS29440 (K5R88_29320) 6461252..6461971 - 720 WP_008026798.1 SDR family oxidoreductase -
K5R88_RS29445 (K5R88_29325) 6462253..6462465 + 213 WP_081501757.1 type II toxin-antitoxin system HicA family toxin Toxin
K5R88_RS29450 (K5R88_29330) 6462465..6462869 + 405 WP_192226071.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K5R88_RS29455 (K5R88_29335) 6462968..6464173 - 1206 WP_226298830.1 MFS transporter -
K5R88_RS29460 (K5R88_29340) 6464388..6465005 + 618 WP_226298831.1 hypothetical protein -
K5R88_RS29465 (K5R88_29345) 6465083..6466078 - 996 WP_008039863.1 sulfate ABC transporter substrate-binding protein -
K5R88_RS29470 (K5R88_29350) 6466172..6466996 - 825 WP_008039865.1 ion transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 7897.06 Da        Isoelectric Point: 10.3517

>T213814 WP_081501757.1 NZ_CP081943:6462253-6462465 [Pseudomonas sp. MM213]
VQSRLLIKELQEAGWTLDRITGSHHLFTHRYNPYTIPVPHPKKDLPTGTVKSIRRRAGLYCPPASHAGDP

Download         Length: 213 bp

>T213814 NZ_CP109874:1922208-1922459 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14763.74 Da        Isoelectric Point: 4.3841

>AT213814 WP_192226071.1 NZ_CP081943:6462465-6462869 [Pseudomonas sp. MM213]
MQYPICIEWGDENTAIGIQIPDIPGAVTAGDTFEDAYNAAIEIAHIMLQELAADGESIPMPTSAAAHRGNPDFADMGWGM
LELDISPYMGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRH

Download         Length: 405 bp

>AT213814 NZ_CP109874:1922456-1922710 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAATGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References