Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-StbC
Location 2129459..2130120 Replicon chromosome
Accession NZ_CP081942
Organism Pseudomonas sp. MM211

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K5Q02_RS09695 Protein ID WP_225838645.1
Coordinates 2129701..2130120 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K5Q02_RS09690 Protein ID WP_225838643.1
Coordinates 2129459..2129704 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5Q02_RS09655 (K5Q02_09630) 2124648..2124935 + 288 WP_225838623.1 hypothetical protein -
K5Q02_RS09660 (K5Q02_09635) 2125143..2126069 - 927 WP_225838624.1 DUF4435 domain-containing protein -
K5Q02_RS09665 (K5Q02_09640) 2126066..2127442 - 1377 WP_225838626.1 AAA family ATPase -
K5Q02_RS09670 (K5Q02_09645) 2127708..2127896 - 189 WP_225838629.1 hypothetical protein -
K5Q02_RS09675 (K5Q02_09650) 2128482..2128853 + 372 WP_225838631.1 excalibur calcium-binding domain-containing protein -
K5Q02_RS09680 (K5Q02_09655) 2128897..2129109 + 213 WP_225838641.1 hypothetical protein -
K5Q02_RS09685 2129189..2129388 + 200 Protein_1908 tyrosine-type recombinase/integrase -
K5Q02_RS09690 (K5Q02_09660) 2129459..2129704 + 246 WP_225838643.1 plasmid stabilization protein Antitoxin
K5Q02_RS09695 (K5Q02_09665) 2129701..2130120 + 420 WP_225838645.1 type II toxin-antitoxin system VapC family toxin Toxin
K5Q02_RS09705 (K5Q02_09675) 2130408..2132162 - 1755 WP_225838647.1 sensor domain-containing diguanylate cyclase -
K5Q02_RS09710 (K5Q02_09680) 2132405..2133505 - 1101 WP_225838657.1 redox-regulated ATPase YchF -
K5Q02_RS09715 (K5Q02_09685) 2133540..2134130 - 591 WP_225838659.1 aminoacyl-tRNA hydrolase -
K5Q02_RS09720 (K5Q02_09690) 2134184..2134804 - 621 WP_225838661.1 50S ribosomal protein L25/general stress protein Ctc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2125143..2133505 8362


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15177.40 Da        Isoelectric Point: 4.4641

>T213809 WP_225838645.1 NZ_CP081942:2129701-2130120 [Pseudomonas sp. MM211]
MILIDTNVLSELMKAKPALEVLSWIDQQPAGELYISSITVAEILYGIARLPDGKRKTAFADLAELMFDEDFSGRVLPFDT
DAAIRYASLAAASEAKGRVSDMADAQIAAIAALYDAPVATRNVRHFDHLGVRVINPWVD

Download         Length: 420 bp

>T213809 NZ_CP109874:224687-224794 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8820.12 Da        Isoelectric Point: 10.0864

>AT213809 WP_225838643.1 NZ_CP081942:2129459-2129704 [Pseudomonas sp. MM211]
MATITIRNLDDDLKAMLRVVAASHGRSMEEEARLIIRQALTKQDKKGGLGSRIHARFSAVGGADLEVPDRITKAKAASFD
E

Download         Length: 246 bp

>AT213809 NZ_CP109874:c224630-224575 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References