Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 417701..418296 Replicon chromosome
Accession NZ_CP081941
Organism Asaia bogorensis strain CSR-2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag K6K47_RS01935 Protein ID WP_222547557.1
Coordinates 418042..418296 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag K6K47_RS01930 Protein ID WP_222547556.1
Coordinates 417701..418045 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6K47_RS01870 412736..412951 - 216 WP_222547544.1 hypothetical protein -
K6K47_RS01875 413057..413380 + 324 WP_222547545.1 hypothetical protein -
K6K47_RS01880 413460..413690 + 231 WP_222547546.1 hypothetical protein -
K6K47_RS01885 413723..414025 + 303 WP_261390427.1 DUF2312 domain-containing protein -
K6K47_RS01890 414029..414361 + 333 WP_222547548.1 hypothetical protein -
K6K47_RS01895 414358..414933 + 576 WP_222547549.1 hypothetical protein -
K6K47_RS01900 414930..415802 + 873 WP_222547550.1 DUF1376 domain-containing protein -
K6K47_RS01905 415799..416602 + 804 WP_222547551.1 hypothetical protein -
K6K47_RS01910 416665..416862 + 198 WP_222547552.1 hypothetical protein -
K6K47_RS01915 416862..417248 + 387 WP_222547553.1 hypothetical protein -
K6K47_RS01920 417248..417517 + 270 WP_222547554.1 hypothetical protein -
K6K47_RS01925 417546..417704 + 159 WP_222547555.1 hypothetical protein -
K6K47_RS01930 417701..418045 - 345 WP_222547556.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K6K47_RS01935 418042..418296 - 255 WP_222547557.1 type II toxin-antitoxin system HicA family toxin Toxin
K6K47_RS01940 418413..418730 + 318 WP_222547558.1 DUF5681 domain-containing protein -
K6K47_RS01945 418727..420091 + 1365 WP_222547559.1 hypothetical protein -
K6K47_RS01950 420134..422344 + 2211 WP_222547560.1 portal protein -
K6K47_RS01955 422341..423213 + 873 WP_222547561.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 402207..487411 85204


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-77)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9386.03 Da        Isoelectric Point: 9.7547

>T213808 WP_222547557.1 NZ_CP081941:c418296-418042 [Asaia bogorensis]
MKSKHIRLLSKIFATPTSGTLVWSEIEALLVSLGCEVEEKTGSAIKIFHGDDLLFLHRPHPQKEAKKYQVREVAAFLTKI
GVTP

Download         Length: 255 bp

>T213808 NZ_CP109874:224203-224310 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12433.95 Da        Isoelectric Point: 4.5625

>AT213808 WP_222547556.1 NZ_CP081941:c418045-417701 [Asaia bogorensis]
MSAMNYKGYFAAITFEADDAVFVGRISGIRDQVVFEGESVSELKAAFENAVDDYLATCAERGREPQKPYSGRLMFRVDPA
LHARVATAADVAGVSLNQWAEKALERAVDADLGR

Download         Length: 345 bp

>AT213808 NZ_CP109874:c224154-224091 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References