Detailed information of TA system TA213807

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1486789..1487391
• Replicon: chromosome
• Accession: NZ_CP081939
• Organism: Avibacterium paragallinarum strain p4chr1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: K5O18_RS07265
• Protein ID: WP_017807336.1
• Coordinates: 1486789..1486965 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: K5O18_RS07270
• Protein ID: WP_194743128.1
• Coordinates: 1486987..1487391 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5O18_RS07215 (K5O18_07215)	1482071..1483420	-	1350	WP_194743086.1	PBSX family phage terminase large subunit	-
K5O18_RS07220 (K5O18_07220)	1483398..1483928	-	531	WP_194743085.1	terminase small subunit	-
K5O18_RS07225 (K5O18_07225)	1483939..1484193	-	255	WP_194743084.1	hypothetical protein	-
K5O18_RS07230 (K5O18_07230)	1484177..1484344	-	168	WP_226537729.1	hypothetical protein	-
K5O18_RS07235 (K5O18_07235)	1484358..1484723	-	366	WP_226537730.1	DUF2570 family protein	-
K5O18_RS07240 (K5O18_07240)	1484680..1485087	-	408	WP_222593582.1	M15 family metallopeptidase	-
K5O18_RS07245 (K5O18_07245)	1485080..1485412	-	333	WP_130239092.1	phage holin, lambda family	-
K5O18_RS07255 (K5O18_07255)	1485685..1486089	-	405	WP_194743130.1	hypothetical protein	-
K5O18_RS07260 (K5O18_07260)	1486089..1486679	-	591	WP_194743129.1	recombination protein NinG	-
K5O18_RS07265 (K5O18_07265)	1486789..1486965	+	177	WP_017807336.1	type II toxin-antitoxin system HicA family toxin	Toxin
K5O18_RS07270 (K5O18_07270)	1486987..1487391	+	405	WP_194743128.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
K5O18_RS07275 (K5O18_07275)	1487672..1488325	+	654	WP_194743127.1	P22AR C-terminal domain-containing protein	-
K5O18_RS07280 (K5O18_07280)	1488391..1488627	+	237	WP_103853789.1	hypothetical protein	-
K5O18_RS07285 (K5O18_07285)	1488736..1489161	-	426	WP_194743126.1	recombination protein NinB	-
K5O18_RS07290 (K5O18_07290)	1489151..1489744	-	594	WP_194743125.1	DNA N-6-adenine-methyltransferase	-
K5O18_RS07295 (K5O18_07295)	1489741..1490580	-	840	WP_194743124.1	ATP-binding protein	-
K5O18_RS07300 (K5O18_07300)	1490573..1491424	-	852	WP_194743123.1	replication protein	-
K5O18_RS07305 (K5O18_07305)	1491421..1492173	-	753	WP_194743122.1	Rha family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1460314..1589338	129024

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6714.77 Da
• Isoelectric Point: 10.6249

>T213807 WP_017807336.1 NZ_CP081939:1486789-1486965 [Avibacterium paragallinarum]
VNSKQMIKLLKQDGWYLDSINGSHHHFEHHQKKGKVTVPHPRAELGHLEKLIRKQAGL

Nucleotide

• Length: 177 bp

>T213807 NZ_CP109874:223721-223828 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14939.02 Da
• Isoelectric Point: 4.7447

>AT213807 WP_194743128.1 NZ_CP081939:1486987-1487391 [Avibacterium paragallinarum]
MLYPIALEKVTDGYVVSVPDIPGCFSAGDTLEEAYNNVKQAITSHLELVVRDNEEVPLPTPLEEHKANPDYQSVDIFFGV
IDVDISHLLGKAERINITMPAYLIKRIDDFVATHPHYKSRSHFLASVSADKIMA

Nucleotide

• Length: 405 bp

>AT213807 NZ_CP109874:c223672-223609 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT