Detailed information of TA system TA213806

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 1469193..1469847
• Replicon: chromosome
• Accession: NZ_CP081939
• Organism: Avibacterium paragallinarum strain p4chr1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0F5EPP6
• Locus tag: K5O18_RS07115
• Protein ID: WP_046099083.1
• Coordinates: 1469193..1469375 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0F5ERJ0
• Locus tag: K5O18_RS07120
• Protein ID: WP_046099082.1
• Coordinates: 1469428..1469847 (+)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5O18_RS07085 (K5O18_07085)	1464795..1466231	-	1437	WP_222593581.1	baseplate J/gp47 family protein	-
K5O18_RS07090 (K5O18_07090)	1466224..1466589	-	366	WP_194743104.1	hypothetical protein	-
K5O18_RS07095 (K5O18_07095)	1466586..1467257	-	672	WP_194743103.1	Gp138 family membrane-puncturing spike protein	-
K5O18_RS07100 (K5O18_07100)	1467250..1468215	-	966	WP_194743102.1	hypothetical protein	-
K5O18_RS07105 (K5O18_07105)	1468193..1468525	-	333	WP_194743101.1	hypothetical protein	-
K5O18_RS07110 (K5O18_07110)	1468525..1469103	-	579	WP_194743100.1	hypothetical protein	-
K5O18_RS07115 (K5O18_07115)	1469193..1469375	+	183	WP_046099083.1	type II toxin-antitoxin system HicA family toxin	Toxin
K5O18_RS07120 (K5O18_07120)	1469428..1469847	+	420	WP_046099082.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
K5O18_RS07125 (K5O18_07125)	1469885..1472077	-	2193	WP_194743099.1	tape measure protein	-
K5O18_RS07130 (K5O18_07130)	1472074..1472226	-	153	WP_017805951.1	hypothetical protein	-
K5O18_RS07135 (K5O18_07135)	1472262..1472747	-	486	WP_194743098.1	hypothetical protein	-
K5O18_RS07140 (K5O18_07140)	1472747..1473175	-	429	WP_194743097.1	DUF3277 family protein	-
K5O18_RS07145 (K5O18_07145)	1473227..1474300	-	1074	WP_194743096.1	DUF3383 family protein	-
K5O18_RS07150 (K5O18_07150)	1474287..1474793	-	507	WP_194743095.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1460314..1589338	129024

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-63)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6957.05 Da
• Isoelectric Point: 10.3460

>T213806 WP_046099083.1 NZ_CP081939:1469193-1469375 [Avibacterium paragallinarum]
MKYSEFLRYLLEQGCKVENTKRGSHRKVTLNGHQTVFPYHGSQEIGTGLVHKIKKDLNLK

Nucleotide

• Length: 183 bp

>T213806 NZ_CP109874:166875-167060 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15815.31 Da
• Isoelectric Point: 4.7276

>AT213806 WP_046099082.1 NZ_CP081939:1469428-1469847 [Avibacterium paragallinarum]
MLRYPVELKADDNGTFLVTFPDIPEAASVGEDLESALLEAEEGLETALEFYFDDKRPIPLPSKPQEGQYTVPLSLLRSLK
VLLLNEMLAQGVRKAEMARRLDVHMPQIDRLLDFRYPSKIDFVEKAFKKLGREIHLAVS

Nucleotide

• Length: 420 bp

>AT213806 NZ_CP109874:167077-167487 [Escherichia coli]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGCCGCGCACTTCGAAACCTTATGCGAGATGG
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCGAAAAGGTTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCAGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA

Structures

Toxin

• AlphaFold DB: A0A0F5EPP6

Antitoxin

• AlphaFold DB: A0A0F5ERJ0