Detailed information of TA system TA213805

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1339227..1339745
• Replicon: chromosome
• Accession: NZ_CP081939
• Organism: Avibacterium paragallinarum strain p4chr1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K5O18_RS06510
• Protein ID: WP_110479438.1
• Coordinates: 1339227..1339421 (-)
• Length: 65 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0F5EVQ3
• Locus tag: K5O18_RS06515
• Protein ID: WP_046098946.1
• Coordinates: 1339455..1339745 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5O18_RS06485 (K5O18_06485)	1334724..1335464	-	741	WP_194742932.1	YebC/PmpR family DNA-binding transcriptional regulator	-
K5O18_RS06490 (K5O18_06490)	1335749..1336207	-	459	WP_110479494.1	dihydroneopterin triphosphate diphosphatase	-
K5O18_RS06495 (K5O18_06495)	1336170..1336559	-	390	WP_110479440.1	hypothetical protein	-
K5O18_RS06500 (K5O18_06500)	1336686..1337291	-	606	WP_226537674.1	hypothetical protein	-
K5O18_RS06505 (K5O18_06505)	1337361..1339139	-	1779	WP_110479439.1	aspartate--tRNA ligase	-
K5O18_RS06510 (K5O18_06510)	1339227..1339421	-	195	WP_110479438.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
K5O18_RS06515 (K5O18_06515)	1339455..1339745	-	291	WP_046098946.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
K5O18_RS06520 (K5O18_06520)	1339937..1340662	+	726	WP_110479437.1	carboxy-S-adenosyl-L-methionine synthase CmoA	-
K5O18_RS06525 (K5O18_06525)	1340783..1341019	-	237	WP_194742933.1	porin	-
K5O18_RS06530 (K5O18_06530)	1340979..1341857	-	879	WP_194742934.1	porin	-
K5O18_RS06535 (K5O18_06535)	1342080..1343153	-	1074	WP_110503383.1	porin	-
K5O18_RS06540 (K5O18_06540)	1343426..1344538	-	1113	WP_110503384.1	porin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (22-63)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-76)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7532.02 Da
• Isoelectric Point: 9.6862

>T213805 WP_110479438.1 NZ_CP081939:c1339421-1339227 [Avibacterium paragallinarum]
MAKEFKRDLVQLAKKAPHLFVHPLKNNLKGYMDCHILNDLVLIYKIEQQCLKLIRLNTHSEVFA

Nucleotide

• Length: 195 bp

>T213805 NZ_CP109872:2320320-2321057 [Bacillus cereus]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAATACTTGTTTTCTTTTATTGGAAAAACGA
AGAGTTGTACGAGGAGAAGAAGCAACGTATTAGAAAGACTTGGTATGGGTTGTTTATAATATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10652.19 Da
• Isoelectric Point: 4.7185

>AT213805 WP_046098946.1 NZ_CP081939:c1339745-1339455 [Avibacterium paragallinarum]
MTNNNAVVNFRLPQHLKTEAFEVIAQYGLTPSQVFNMFLTEIAATKAIPLSLNYLQPNAKTLAAMNEIESGTAERLSLDD
KTDLATLLQQIAEEKK

Nucleotide

• Length: 291 bp

>AT213805 NZ_CP109872:2321170-2321295 [Bacillus cereus]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0F5EVQ3