Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 967864..969497 Replicon chromosome
Accession NZ_CP081939
Organism Avibacterium paragallinarum strain p4chr1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag K5O18_RS04830 Protein ID WP_110478934.1
Coordinates 967864..969171 (+) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K5O18_RS04835 Protein ID WP_222593804.1
Coordinates 969171..969497 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5O18_RS04805 (K5O18_04805) 962965..963999 + 1035 WP_110478928.1 thiamine-phosphate kinase -
K5O18_RS04810 (K5O18_04810) 964005..964505 + 501 WP_110478929.1 phosphatidylglycerophosphatase A -
K5O18_RS04815 (K5O18_04815) 964517..965152 + 636 WP_110478930.1 LysE family transporter -
K5O18_RS04820 (K5O18_04820) 965167..965979 + 813 WP_110478931.1 4-hydroxy-tetrahydrodipicolinate reductase -
K5O18_RS04825 (K5O18_04825) 967516..967764 + 249 WP_110478933.1 class I ribonucleotide reductase maintenance protein YfaE -
K5O18_RS04830 (K5O18_04830) 967864..969171 + 1308 WP_110478934.1 HipA domain-containing protein Toxin
K5O18_RS04835 (K5O18_04835) 969171..969497 + 327 WP_222593804.1 helix-turn-helix domain-containing protein Antitoxin
K5O18_RS04840 (K5O18_04840) 969538..970668 - 1131 WP_017806521.1 class Ia ribonucleoside-diphosphate reductase subunit beta -
K5O18_RS04845 (K5O18_04845) 970830..971252 - 423 WP_110478936.1 DUF1043 family protein -
K5O18_RS04850 (K5O18_04850) 971387..973156 - 1770 WP_110478937.1 30S ribosomal protein S12 methylthiotransferase accessory factor YcaO -
K5O18_RS04855 (K5O18_04855) 973263..973994 - 732 WP_110478938.1 methyltransferase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(158-351)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-90)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 50336.30 Da        Isoelectric Point: 5.9938

>T213803 WP_110478934.1 NZ_CP081939:967864-969171 [Avibacterium paragallinarum]
MEKLILQTYIDQEWRDMAELHFEKETYQLSNLVYFPDYITQYFGQEGSRAVSINYPVHIFIENRKTLWSCIGDIAPAGAS
RRYWIESLDIKHLPESEQNYRLLKYGAISPVGNLRIKEATPQKTEVRYFDIEKVKDRQSDFLEYANQSGAMVGGATGAGG
EAPKLLLKRHNGKVWIDNLQDGKDQDISYLVKYPRGRYSSIDCDILRAEFHYYQEVAELGFDTIDIHHMCLEEGERYPSL
WLPRFDITKKEGKYNRLALESVYSMLQKQGGTLEHEATIRQLIKIISASNLEFDQQHFVLEWVKRDLLNIAFGNSDNHGR
NMAFLRDEQKIWLAPIYDFAPMRADPEGIIRSTTWNRKGSLPQEFAGEYRFDLIAESLSDLIEPSLLLTKLQQLAIRLVD
LKSRLAQRGVPQAILDHPSIGFDYLPEKLKAWGLV

Download         Length: 1308 bp

>T213803 NZ_CP109859:200669-201019 [Priestia megaterium]
TTGGTAGTCAAACGTGGCGACGTTTATTTTGCTGACCTATCTCCTGTTGTTGGCTCAGAACAAGGAGGCGTTCGCCCTGT
ACTTGTCATTCAAAATGATATAGGCAATCGTTTTAGCCCAACTGTTATTGTAGCTGCGATCACTGCTCAAATTCAAAAGG
CAAAGTTACCTACGCATGTTGAAATTGATGCAAAGCGCTATGGATTTGAGCGAGATTCAGTTATTTTACTAGAACAAATT
CGTACTATTGATAAACAGAGGCTAACAGACAAGATTACCCATTTAGATGATGAAATGATGGACAGAGTGGATGAAGCCTT
GCAAATCAGTGTAGGACTTATCGACTTTTAG

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12235.43 Da        Isoelectric Point: 11.1419

>AT213803 WP_222593804.1 NZ_CP081939:969171-969497 [Avibacterium paragallinarum]
MITRKNASKVGATISTTERNNVRNRIIKALLLGKMTQGQALRKLRIEMLGVNQQQYMKMVKVSRQTLSNIENDKGNYSVA
TINQVFKPFGFELGLVPISKELLTEIMH

Download         Length: 327 bp

>AT213803 NZ_CP109859:200383-200664 [Priestia megaterium]
GTGTCTGAAGCGAGCGCAACTACAGAAATCCTAGTAAGATTACCGAAAAATTTAGTATCGGAGCTCGATCTTATGGTTAA
ACAAGAAAATGGCAACCGAAGTGATTTTATTCACCAAGCAACAAAATTGTACCTTCGTGAGCGAAAAAAACGCCATATTC
GCGAATCAATGAGACGTGGATATATGGAGATGGCAAAGATAAACTTAAATATTGCTTCCGAGGCTTTTCTAGCAGAGTAT
GAAGCTGATCATACTGTGGATCGTTTAGTAAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References