Detailed information of TA system TA213802

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 651661..652287
• Replicon: chromosome
• Accession: NZ_CP081939
• Organism: Avibacterium paragallinarum strain p4chr1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A2S5AWB0
• Locus tag: K5O18_RS03190
• Protein ID: WP_017807138.1
• Coordinates: 652105..652287 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A2S5AX18
• Locus tag: K5O18_RS03185
• Protein ID: WP_017807139.1
• Coordinates: 651661..652068 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5O18_RS03160 (K5O18_03160)	646861..647805	-	945	WP_261764826.1	GPO family capsid scaffolding protein	-
K5O18_RS03165 (K5O18_03165)	647849..649771	+	1923	WP_261764827.1	terminase family protein	-
K5O18_RS03170 (K5O18_03170)	649737..650774	+	1038	WP_110478438.1	phage portal protein	-
K5O18_RS03175 (K5O18_03175)	650855..651112	+	258	WP_110478437.1	ogr/Delta-like zinc finger family protein	-
K5O18_RS03180 (K5O18_03180)	651421..651648	+	228	WP_110478436.1	hypothetical protein	-
K5O18_RS03185 (K5O18_03185)	651661..652068	-	408	WP_017807139.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
K5O18_RS03190 (K5O18_03190)	652105..652287	-	183	WP_017807138.1	type II toxin-antitoxin system HicA family toxin	Toxin
K5O18_RS03195 (K5O18_03195)	652929..653474	-	546	WP_035688593.1	phage N-6-adenine-methyltransferase	-
K5O18_RS03200 (K5O18_03200)	653507..655921	-	2415	WP_222593751.1	replication endonuclease	-
K5O18_RS03205 (K5O18_03205)	655943..656221	-	279	WP_035688595.1	hypothetical protein	-
K5O18_RS03210 (K5O18_03210)	656234..656440	-	207	WP_017807131.1	hypothetical protein	-
K5O18_RS03215 (K5O18_03215)	656424..656789	-	366	WP_110478434.1	hypothetical protein	-
K5O18_RS03220 (K5O18_03220)	656776..656922	-	147	WP_165816385.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	608861..669537	60676

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6714.92 Da
• Isoelectric Point: 11.2162

>T213802 WP_017807138.1 NZ_CP081939:c652287-652105 [Avibacterium paragallinarum]
VNSANLIKQVEKDGWVLVSVKGSHHQFKHPTKKGRVTIPHPKKDLHIKTVNSILKQAGLK

Nucleotide

• Length: 183 bp

>T213802 NZ_CP109856:c5269155-5268877 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTAGGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14984.09 Da
• Isoelectric Point: 4.5312

>AT213802 WP_017807139.1 NZ_CP081939:c652068-651661 [Avibacterium paragallinarum]
MLYPIGIEMGDEKHAYGVVVPDVPGCFSAGDTLEEAFTNAKEAIAFHIEGMLEDGEEIPLPTDLQRHMQNKEYEGFTFTV
VDVDLTHLMGKAEKINVTLPKILINKIDNYVSTHPQYKSRSGFLAQIATDKLLSA

Nucleotide

• Length: 408 bp

>AT213802 NZ_CP109856:c5268865-5268560 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Structures

Toxin

• AlphaFold DB: A0A2S5AWB0

Antitoxin

• AlphaFold DB: A0A2S5AX18