Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-YefM
Location 304945..305655 Replicon chromosome
Accession NZ_CP081939
Organism Avibacterium paragallinarum strain p4chr1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K5O18_RS01455 Protein ID WP_110478604.1
Coordinates 304945..305364 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K5O18_RS01460 Protein ID WP_110478603.1
Coordinates 305380..305655 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5O18_RS01430 (K5O18_01430) 299969..301051 - 1083 WP_110478657.1 extracellular solute-binding protein -
K5O18_RS01435 (K5O18_01435) 301075..301917 - 843 WP_039085670.1 ABC transporter permease -
K5O18_RS01440 (K5O18_01440) 301914..302783 - 870 WP_039085672.1 ABC transporter permease -
K5O18_RS01445 (K5O18_01445) 302780..303853 - 1074 WP_110478606.1 ABC transporter ATP-binding protein -
K5O18_RS01450 (K5O18_01450) 304089..304913 + 825 WP_110478605.1 glycerophosphodiester phosphodiesterase family protein -
K5O18_RS01455 (K5O18_01455) 304945..305364 - 420 WP_110478604.1 type II toxin-antitoxin system VapC family toxin Toxin
K5O18_RS01460 (K5O18_01460) 305380..305655 - 276 WP_110478603.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K5O18_RS01465 (K5O18_01465) 305842..306477 - 636 WP_110478602.1 bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase -
K5O18_RS01470 (K5O18_01470) 306488..307429 - 942 WP_110478601.1 sugar kinase -
K5O18_RS01475 (K5O18_01475) 307589..308377 + 789 WP_110478600.1 DNA-binding transcriptional regulator KdgR -
K5O18_RS01480 (K5O18_01480) 308427..309011 - 585 WP_261764888.1 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase KduD -
K5O18_RS13990 308893..309195 - 303 WP_261764898.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15774.45 Da        Isoelectric Point: 7.1333

>T213800 WP_110478604.1 NZ_CP081939:c305364-304945 [Avibacterium paragallinarum]
MYLLDTNIISELYKFRNGKINAGVKAWLAEILPSETAISCITLSEIQTGILLKARRDKTQAALLNEWFKQQIIPVYQQNT
LPITAEIALMAAELHIPNKMDINDAYIAATAKFHRLKLVTRNIKDFENCGIEIINPFLD

Download         Length: 420 bp

>T213800 NZ_CP109856:3513600-3514178 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCAGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10623.98 Da        Isoelectric Point: 4.8483

>AT213800 WP_110478603.1 NZ_CP081939:c305655-305380 [Avibacterium paragallinarum]
MAITVTSKEFNQRASYVLKLSETQPVFITKWGKIVSVLSNYRDYRKTQSEPSFEELFGQPTPPVSDKDIEDFDQILTEIR
KNTHIREVELD

Download         Length: 276 bp

>AT213800 NZ_CP109856:3512957-3513511 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAGACCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References