Detailed information of TA system TA213798

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/Txe-RelB
• Location: 1962963..1963483
• Replicon: chromosome
• Accession: NZ_CP081913
• Organism: Bacteroides stercoris strain BFG-121

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A108TAT8
• Locus tag: K6V31_RS08420
• Protein ID: WP_060385334.1
• Coordinates: 1963214..1963483 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: K6V31_RS08415
• Protein ID: WP_022103880.1
• Coordinates: 1962963..1963217 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6V31_RS08395 (K6V31_08350)	1959776..1960189	-	414	WP_022103883.1	hypothetical protein	-
K6V31_RS08400 (K6V31_08355)	1960358..1961419	+	1062	WP_117739960.1	3-dehydroquinate synthase	-
K6V31_RS08405 (K6V31_08360)	1961425..1962477	-	1053	WP_165438839.1	winged helix DNA-binding domain-containing protein	-
K6V31_RS08415 (K6V31_08370)	1962963..1963217	+	255	WP_022103880.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
K6V31_RS08420 (K6V31_08375)	1963214..1963483	+	270	WP_060385334.1	Txe/YoeB family addiction module toxin	Toxin
K6V31_RS08425 (K6V31_08380)	1963950..1965141	+	1192	Protein_1643	site-specific integrase	-
K6V31_RS08430 (K6V31_08385)	1965159..1965551	+	393	WP_117940831.1	hypothetical protein	-
K6V31_RS08435 (K6V31_08390)	1965604..1965972	+	369	WP_224200054.1	hypothetical protein	-
K6V31_RS08440 (K6V31_08395)	1966128..1967495	+	1368	WP_060385332.1	MobV family relaxase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10847.69 Da
• Isoelectric Point: 10.0340

>T213798 WP_060385334.1 NZ_CP081913:1963214-1963483 [Bacteroides stercoris]
MKLIFTPIAQEHWEYWKKNDPNITKRIKKLLADILEHPYTGIGKPEPLKYELAGKWSRRINTEHRLIYSVHNDMIEIYIF
SMKYHYSKK

Nucleotide

• Length: 270 bp

>T213798 NZ_CP109856:c143142-142861 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9457.56 Da
• Isoelectric Point: 4.0834

>AT213798 WP_022103880.1 NZ_CP081913:1962963-1963217 [Bacteroides stercoris]
MKTTNYTDLRANLKGYIDSVIDDCDTVFINRGNGTGVVMISLEEYNSLKETEYIMSSEQTMNDIRKGEEDLKAGKGIEVN
LDEL

Nucleotide

• Length: 255 bp

>AT213798 NZ_CP109856:c143366-143139 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Toxin

• AlphaFold DB: A0A108TAT8