Detailed information of TA system TA213797

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/Txe-RelB
• Location: 6256043..6256563
• Replicon: chromosome
• Accession: NZ_CP081903
• Organism: Bacteroides cellulosilyticus strain BFG-250

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K6V21_RS24090
• Protein ID: WP_224320138.1
• Coordinates: 6256294..6256563 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: K6V21_RS24085
• Protein ID: WP_224320137.1
• Coordinates: 6256043..6256297 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6V21_RS24065 (K6V21_23965)	6251095..6251649	-	555	WP_217714731.1	RNA polymerase sigma-70 factor	-
K6V21_RS24070 (K6V21_23970)	6251807..6253552	+	1746	WP_224320136.1	pectate lyase	-
K6V21_RS24075 (K6V21_23975)	6253728..6254429	+	702	WP_007664170.1	nitrogen-fixing protein NifU	-
K6V21_RS24080 (K6V21_23980)	6254449..6255459	+	1011	WP_022392200.1	GGGtGRT protein	-
K6V21_RS24085 (K6V21_23985)	6256043..6256297	+	255	WP_224320137.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
K6V21_RS24090 (K6V21_23990)	6256294..6256563	+	270	WP_224320138.1	Txe/YoeB family addiction module toxin	Toxin
K6V21_RS24095 (K6V21_23995)	6257135..6258733	+	1599	WP_224320139.1	leucine-rich repeat domain-containing protein	-
K6V21_RS24100 (K6V21_24000)	6259483..6261441	+	1959	WP_224320140.1	LruC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10844.65 Da
• Isoelectric Point: 10.1205

>T213797 WP_224320138.1 NZ_CP081903:6256294-6256563 [Bacteroides cellulosilyticus]
MKVIFSPLAMEQWEYWKKNNPNIAKRIKKILLDIREHPYTGIAKPEPLKYDLAGKWSRRINEEHRIIYSVNDDRIEIDIL
SMRYHYSKK

Nucleotide

• Length: 270 bp

>T213797 NZ_CP109854:c641032-640697 [Pantoea dispersa]
GTGACGGGTAATTATCTGGAATTTATCGAAACGCGCGTGTTTTCAAAAGCTCGTCAGAGTCTGCTGGCAGACGATCAAGA
ATTTCAGGAACTGCAAATTTTTTTGCTTGAGCATCATGAGTTAGGTGACACCATTAGTCAGACCGGAGGATGCAAAAAGA
TTCGCTGGAGCCGGGCCGGAATGGGTAAACGTGGTGGAACAAGGATTATTTATTACACCCGCCTGAGCTCAGGCAGAATT
TATCTGTTACTCATCTATCCCAAAAATGTGAAGGATGATTTAAATGAAGCAGAAAAAGCGTTGCTAAAAGTCTTTACCCA
ACAAATGAACCTCTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9406.50 Da
• Isoelectric Point: 4.0721

>AT213797 WP_224320137.1 NZ_CP081903:6256043-6256297 [Bacteroides cellulosilyticus]
MRTANYTDLRANLKGYIDSVIDDYDTVIVNRGNGKGVVMISLDEYNSLKETEYIMSSPATMEAIRQGEEDIKNGKGIEVD
LDEL

Nucleotide

• Length: 255 bp

>AT213797 NZ_CP109854:c640671-640375 [Pantoea dispersa]
ATGGAAAAACAGCTATTTAATGACCTGCTGGAAAGCGTACAGGAAATGGTCGCCATTGAGCAGGGTCATGAATCACCGGA
TATGAACCGCGTCCACCGTCATGAACTGCCGGATGTAAAGCTGATCAGAAAGAATGCTGGGCTAAAACAAGTTGAATTTG
CCCATGCGATGGGCGTTAGCGTGGATCTTATTCGTAGCTGGGAGCAGCACAGACGCAACCCTACCGGTCCAGCATTGAAA
ATGCTTTATCTGATTCAGCAGCAGCCATTACTCATCAATGCTTTACAGGCGCTGTAA