Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4689523..4690039 Replicon chromosome
Accession NZ_CP081897
Organism Klebsiella pneumoniae strain MN-03

Toxin (Protein)


Gene name relE Uniprot ID A0A483NZA3
Locus tag KZ659_RS22955 Protein ID WP_004894697.1
Coordinates 4689523..4689807 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KZ659_RS22960 Protein ID WP_002886901.1
Coordinates 4689797..4690039 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ659_RS22930 (KZ659_22850) 4684918..4685181 - 264 WP_031280360.1 PTS sugar transporter subunit IIB -
KZ659_RS22935 (KZ659_22855) 4685311..4685484 + 174 WP_002886906.1 hypothetical protein -
KZ659_RS22940 (KZ659_22860) 4685487..4686230 + 744 WP_004894691.1 MurR/RpiR family transcriptional regulator -
KZ659_RS22945 (KZ659_22865) 4686588..4688726 + 2139 WP_023325427.1 anaerobic ribonucleoside-triphosphate reductase -
KZ659_RS22950 (KZ659_22870) 4689055..4689519 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KZ659_RS22955 (KZ659_22875) 4689523..4689807 - 285 WP_004894697.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KZ659_RS22960 (KZ659_22880) 4689797..4690039 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KZ659_RS22965 (KZ659_22885) 4690117..4692027 - 1911 WP_023325426.1 PRD domain-containing protein -
KZ659_RS22970 (KZ659_22890) 4692050..4693204 - 1155 WP_004178372.1 lactonase family protein -
KZ659_RS22975 (KZ659_22895) 4693271..4694011 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11174.05 Da        Isoelectric Point: 10.3787

>T213795 WP_004894697.1 NZ_CP081897:c4689807-4689523 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIMQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T213795 NZ_CP109854:569131-569502 [Pantoea dispersa]
GTGTGGCAGGTTGAAGCAACAGATCGGTTTTGGAAATGGTTGCAGGCTCAGGATGAAGCGTTGCGTCTCGATGTGCTTGC
CGCCATGAAGCTTCTGGCGCAGTACGGTCCGCACCTCGGCCGCCCTTTCGTTGATACCCTGATGTTATCGCGGGTGCCCA
ATATGAAAGAGCTACGCGTGCAAAGTAAAGGTCGTCCCATCCGCAGCTTTTTTGTTTTCGATCCGCGCCGCCATGCGATT
GTGCTGTGTGCCGGCAACAAACAGGGTAAAAATCAGAAGCGTTTCTATCAGCAGATGCTTCGCATTGCCGAAACCGAATA
CCATCATCATCTGAACGCAATCGGGGAAACTCATAATGAAAACCTTGGATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT213795 WP_002886901.1 NZ_CP081897:c4690039-4689797 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT213795 NZ_CP109854:569486-569785 [Pantoea dispersa]
ATGAAAACCTTGGATGAGATGCTGGCGGCGCTGACGCCCGAACAGCAACATCAGGTCGATGAACGCGTCAGCCAGATGCG
TCTTGAATACCAGCTTTACCAATTACGTGAGCAGATGCAGCGGACTCAGCGTCAGCAAGCGCAGGCCATGCACATTGCCC
AGTCATCTGTGGCGGCGATGGAAGCGCGTGGCGCAGAGTTAAAAATTTCCACGCTGAAGCGCTACATTGAGGCGCTGGGT
GGAGAGCTGACGCTGGGTGTAAAGATGCCGGGTGGCCAGCATGTCGACTTAATTATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483NZA3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References