Detailed information of TA system TA213794

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 4609223..4609869
• Replicon: chromosome
• Accession: NZ_CP081897
• Organism: Klebsiella pneumoniae strain MN-03

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: KZ659_RS22590
• Protein ID: WP_017880111.1
• Coordinates: 4609223..4609564 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: KZ659_RS22595
• Protein ID: WP_229553719.1
• Coordinates: 4609585..4609869 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZ659_RS22565 (KZ659_22485)	4605794..4606921	+	1128	WP_023325431.1	PAAR domain-containing protein	-
KZ659_RS22570 (KZ659_22490)	4606941..4607174	+	234	WP_014908049.1	hypothetical protein	-
KZ659_RS22575 (KZ659_22495)	4607320..4607454	+	135	Protein_4426	transposase	-
KZ659_RS22580 (KZ659_22500)	4607467..4607577	-	111	Protein_4427	DUF4102 domain-containing protein	-
KZ659_RS22585 (KZ659_22505)	4607952..4608959	-	1008	WP_017880110.1	restriction endonuclease	-
KZ659_RS22590 (KZ659_22510)	4609223..4609564	-	342	WP_017880111.1	TA system toxin CbtA family protein	Toxin
KZ659_RS22595 (KZ659_22515)	4609585..4609869	-	285	WP_229553719.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
KZ659_RS22600 (KZ659_22520)	4609937..4610479	-	543	WP_017880113.1	DNA repair protein RadC	-
KZ659_RS22605 (KZ659_22525)	4610492..4610935	-	444	WP_017880114.1	antirestriction protein	-
KZ659_RS22610 (KZ659_22530)	4610966..4611787	-	822	WP_017880115.1	DUF932 domain-containing protein	-
KZ659_RS22615 (KZ659_22535)	4611908..4612381	-	474	WP_031280324.1	hypothetical protein	-
KZ659_RS22620 (KZ659_22540)	4612453..4612905	-	453	WP_031280325.1	hypothetical protein	-
KZ659_RS22625 (KZ659_22545)	4612941..4613657	-	717	WP_032417794.1	WYL domain-containing protein	-
KZ659_RS22630 (KZ659_22550)	4613901..4614776	-	876	WP_017880120.1	GTPase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4591572..4637499	45927

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-109)

Antitoxin

• Antitoxin CbeA (1-92)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12811.73 Da
• Isoelectric Point: 8.4941

>T213794 WP_017880111.1 NZ_CP081897:c4609564-4609223 [Klebsiella pneumoniae]
MKTLPATNPQAATLYLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
DWQEQSPYLRAVDIMRARQATGLLKRNRISAAR

Nucleotide

• Length: 342 bp

>T213794 NZ_CP109854:c508708-508325 [Pantoea dispersa]
ATGGCCATTTATGTATTGAAGCCCTTCGACCGAAATTTCAAAGGTGACATGATTGCGGACATCAAGCTCTGTCTGGCTGC
CCGCGAATTGATTGCCGGACAGTATGAGGCCAGCCTGGGGGGTGGTGTTTACAAAAAACGCATTCCGCTCGGCGCCGGCA
AAAGCGGCGGAGCCAGAGCGATTGTCGCGTTCAAATCACAAAAACACCTGTTTTTTGTTAACGGTTACGCTAAATCGACC
ACGAAGAGTGGCATACGTGAGATTAAAGAGGATGAGATTAATTTCTACAGGCAGGTAGCCAGTCAACTGTTTGCCATGAC
GACTGAGCAGGAAAGAGCAGCGATAAAGGCGAGAAAAATGCGAGAGGTAATATGCGATGGTTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10650.07 Da
• Isoelectric Point: 6.6243

>AT213794 WP_229553719.1 NZ_CP081897:c4609869-4609585 [Klebsiella pneumoniae]
MTPCFGARLVQEGNRLHYLADRACITGEFSNAESLKLDEVFTRFIRQMESMLTTGEMNPRHAHSVTLYHNGFTCEADTLG
SCGYVYIAVYPTHR

Nucleotide

• Length: 285 bp

>AT213794 NZ_CP109854:c508332-508006 [Pantoea dispersa]
ATGGTTGATCATCTAAAAGATCTGCAGGAAATCGCGCATGATTTTAACCCGCTGGGGGTGATTAGCGATGAGCTTACCGA
AAAAATCGATTCACGTGTCAGATTACGTGAGCTGCGTACCTCTCTGCCGGTTTTACAACTGATGTCAGGCGAGGCTATTC
GTGAGTTACGTGAGCGTCATGGTCTGAGTCAGGCCATGTTAGCCGCCTATATTGGCCTGTCTCCGGCCACCGTGGTGAAA
TGGGAGCGCGAGGAGAAAAAGCCAAATGGCGCTGCGCTGCGCCTGCTTAACCTCATTGATAGAAAGGGTCTTGAGGTATT
GCGTTAA