Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2575468..2577056 Replicon chromosome
Accession NZ_CP081897
Organism Klebsiella pneumoniae strain MN-03

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag KZ659_RS12685 Protein ID WP_004892016.1
Coordinates 2575468..2576790 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag KZ659_RS12690 Protein ID WP_004176198.1
Coordinates 2576790..2577056 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ659_RS12670 (KZ659_12625) 2570524..2573025 + 2502 WP_004892009.1 fimbria/pilus outer membrane usher protein -
KZ659_RS12675 (KZ659_12630) 2573013..2574017 + 1005 WP_004892012.1 fimbrial protein -
KZ659_RS12680 (KZ659_12635) 2574159..2575451 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
KZ659_RS12685 (KZ659_12640) 2575468..2576790 - 1323 WP_004892016.1 type II toxin-antitoxin system HipA family toxin Toxin
KZ659_RS12690 (KZ659_12645) 2576790..2577056 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
KZ659_RS12695 (KZ659_12650) 2577321..2577647 - 327 WP_004892019.1 hydroxyisourate hydrolase -
KZ659_RS12700 (KZ659_12655) 2577644..2578144 - 501 WP_004892023.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
KZ659_RS12705 (KZ659_12660) 2578122..2579501 - 1380 WP_004176204.1 nucleobase:cation symporter-2 family protein -
KZ659_RS12710 (KZ659_12665) 2579847..2581001 + 1155 WP_004892025.1 FAD-dependent urate hydroxylase HpxO -
KZ659_RS12715 (KZ659_12670) 2580982..2581905 - 924 WP_004892028.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T213790 WP_004892016.1 NZ_CP081897:c2576790-2575468 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T213790 NZ_CP109853:3703935-3704399 [Pantoea dispersa]
GTGATTTTTTATCGGCTGACGAAGAGCCAGTATGCGGCTGAAGCCTGGTCCGGTTATGGGGCAAAACAGTATGGTGGACG
CTGGAATCATAAAGGCTATCCCACCGTTTATGTTGCCACGTCGGTGTCACTCGCAGCACTGGAAGTGCTGGTCCATATCG
GAAGAGAGTCGGTGCTGGATGAGTACACCTTATTCAGTATCGACATCCCGGATGCAGAAGTTGCCTATCTTGCTGAAGCA
TTTTTGCCGCCGGACTGGCGTCATGATCCAGCGCCACTCTCGACAATGGATCTCGGCACCGGCTGGCTGCAATCCGCTGA
AGGCGCCGCGCTGATGCTACCTTCCACGATTATCCCGATGGAAAACAACGCCATTCTGAACCCTCTCCATCCTGCCTTTA
GTGACTATCTGCCGGGCGTGAAAGCGTTACCGTTTATGTTTGATCGCCGGCTTATCAGGACATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT213790 WP_004176198.1 NZ_CP081897:c2577056-2576790 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT213790 NZ_CP109853:3703495-3703938 [Pantoea dispersa]
ATGCGAGCTTATATTCCTCAGCCTGGAGCCAATGACAACGCGCTGTGGCGGGTTGCAGGCCTGCCTCCACGTGGTATTGA
GTTAACGCGTATGCTGGAAGCCGGTTTGCCGGTGGCCGTCATTGATGATATCCGTCACTGGTCGGCCATGACGCGCGCCG
AAATCATGAAGGTCACAGGGATTAATGAACGCAACATTGCCCGTCGTAAAAGCACGGGTAAAAGTCTGTCACCCGACGAG
AGTGAACGTGTCGCCCGCTTCGTCCGCGTGATGGATGCCGCCGTTCAGCTTTTTGCTGGTAATAAAGAAGAGGCCACCCA
GTGGCTGAGCCGACCGGTGAAAGGGTTAGGCAATGTTGCGCCCATCACCTTACTGACGACGGAGAGCGGTGCGCTGGATG
TTCTCGATTTGATCGGCCGTCTGGAGCACGGTGTTTTCTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References