Detailed information of TA system TA021378

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2030547..2031200
• Replicon: chromosome
• Accession: NC_007643
• Organism: Rhodospirillum rubrum ATCC 11170

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q2RTK6
• Locus tag: RRU_RS09025
• Protein ID: WP_011389492.1
• Coordinates: 2031006..2031200 (-)
• Length: 65 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: Q2RTK7
• Locus tag: RRU_RS09020
• Protein ID: WP_011389491.1
• Coordinates: 2030547..2030933 (-)
• Length: 129 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RRU_RS08980	2025767..2026294	+	528	WP_011389483.1	thermonuclease family protein	-
RRU_RS08985	2026315..2026647	-	333	WP_011389484.1	hypothetical protein	-
RRU_RS08990	2026738..2027199	-	462	WP_011389485.1	LysM domain-containing protein	-
RRU_RS08995	2027225..2028361	-	1137	WP_011389486.1	SPOR domain-containing protein	-
RRU_RS09000	2028394..2028669	-	276	WP_014626238.1	hypothetical protein	-
RRU_RS09005	2028832..2029596	-	765	WP_011389488.1	protein phosphatase CheZ	-
RRU_RS09010	2029960..2030223	+	264	WP_011389489.1	hypothetical protein	-
RRU_RS09015	2030229..2030507	+	279	WP_011389490.1	hypothetical protein	-
RRU_RS09020	2030547..2030933	-	387	WP_011389491.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
RRU_RS09025	2031006..2031200	-	195	WP_011389492.1	type II toxin-antitoxin system HicA family toxin	Toxin
RRU_RS09030	2031329..2031502	+	174	WP_158308122.1	hypothetical protein	-
RRU_RS09035	2031665..2032000	+	336	WP_011389493.1	hypothetical protein	-
RRU_RS09040	2031997..2032863	+	867	WP_014626239.1	tyrosine-type recombinase/integrase	-
RRU_RS09050	2033249..2033809	-	561	WP_014626240.1	peptidylprolyl isomerase	-
RRU_RS09055	2033852..2034370	-	519	WP_011389496.1	pantetheine-phosphate adenylyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2030547..2040716	10169

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-120)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7295.51 Da
• Isoelectric Point: 11.4226

>T21378 WP_011389492.1 NC_007643:c2031200-2031006 [Rhodospirillum rubrum ATCC 11170]
MDSREVVKRLKADGWRVVDQPGSHLQLKHPIKRGRVTVPHPEKDLKPGTLRSIEKQSGVSMRKT

Nucleotide

• Length: 195 bp

>T21378 NC_007643:c2031200-2031006 [Rhodospirillum rubrum ATCC 11170]
ATGGACAGTCGAGAAGTCGTCAAGCGGTTGAAGGCCGATGGATGGAGGGTGGTTGATCAGCCGGGGAGCCACCTGCAACT
GAAGCATCCCATCAAACGCGGCCGCGTCACTGTCCCCCACCCCGAAAAGGATCTAAAGCCTGGAACTCTCCGTTCTATCG
AGAAGCAAAGCGGGGTCTCTATGAGAAAAACCTAA

Antitoxin

Protein

• Length: 129 a.a.
• Molecular weight: 13338.09 Da
• Isoelectric Point: 3.7858

>AT21378 WP_011389491.1 NC_007643:c2030933-2030547 [Rhodospirillum rubrum ATCC 11170]
MNYTYAVVIETDDLGGFSAFFPDLPGCVGAGDSVEACFQDALDALALHLAGMIEDGDSLPAPTPLSDVEVDPDIQVAAIL
LASVPVTGRTMRVNITMDATLVAAIDGVTSNRSAWLADAALRALRSNR

Nucleotide

• Length: 387 bp

>AT21378 NC_007643:c2030933-2030547 [Rhodospirillum rubrum ATCC 11170]
ATGAACTATACTTACGCCGTTGTAATCGAAACCGATGACCTTGGCGGGTTTAGCGCCTTTTTCCCCGATCTTCCCGGCTG
CGTCGGAGCGGGGGATAGCGTGGAAGCGTGCTTTCAAGATGCTCTGGACGCACTTGCACTGCATCTTGCAGGTATGATCG
AAGATGGTGACAGCCTGCCCGCCCCCACCCCTTTGTCTGATGTCGAAGTCGATCCCGATATTCAGGTGGCGGCTATTCTG
TTGGCTTCGGTTCCCGTAACGGGGCGGACGATGCGTGTGAACATCACCATGGATGCAACACTCGTGGCCGCCATTGATGG
CGTGACATCCAACCGAAGCGCCTGGCTGGCCGATGCCGCCTTGCGCGCGTTGCGAAGCAATCGGTAG

Structures

Toxin

• AlphaFold DB: Q2RTK6

Antitoxin

• AlphaFold DB: Q2RTK7