Detailed information of TA system TA213775

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4660385..4660901
• Replicon: chromosome
• Accession: NZ_CP081896
• Organism: Klebsiella pneumoniae strain PA-01

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KZ665_RS22860
• Protein ID: WP_040225317.1
• Coordinates: 4660385..4660669 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: KZ665_RS22865
• Protein ID: WP_002886901.1
• Coordinates: 4660659..4660901 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZ665_RS22835 (KZ665_22755)	4655860..4656123	-	264	WP_004152271.1	PTS sugar transporter subunit IIB	-
KZ665_RS22840 (KZ665_22760)	4656253..4656426	+	174	WP_065900585.1	hypothetical protein	-
KZ665_RS22845 (KZ665_22765)	4656429..4657172	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
KZ665_RS22850 (KZ665_22770)	4657529..4659667	+	2139	WP_049117635.1	anaerobic ribonucleoside-triphosphate reductase	-
KZ665_RS22855 (KZ665_22775)	4659917..4660381	+	465	WP_004222151.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
KZ665_RS22860 (KZ665_22780)	4660385..4660669	-	285	WP_040225317.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KZ665_RS22865 (KZ665_22785)	4660659..4660901	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KZ665_RS22870 (KZ665_22790)	4660979..4662889	-	1911	WP_102007830.1	PRD domain-containing protein	-
KZ665_RS22875 (KZ665_22795)	4662912..4664066	-	1155	WP_023301365.1	lactonase family protein	-
KZ665_RS22880 (KZ665_22800)	4664133..4664873	-	741	WP_004186692.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11172.02 Da
• Isoelectric Point: 10.3787

>T213775 WP_040225317.1 NZ_CP081896:c4660669-4660385 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T213775 NZ_CP109850:4015127-4015474 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGTTCCATTCCA
AGGTGAACAGGCTGCATTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGTGGCAGTGATCTTGGTTTTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT213775 WP_002886901.1 NZ_CP081896:c4660901-4660659 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT213775 NZ_CP109850:4014866-4015117 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGATCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0