Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3936386..3937005 Replicon chromosome
Accession NZ_CP081896
Organism Klebsiella pneumoniae strain PA-01

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KZ665_RS19385 Protein ID WP_002892050.1
Coordinates 3936787..3937005 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KZ665_RS19380 Protein ID WP_002892066.1
Coordinates 3936386..3936760 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ665_RS19370 (KZ665_19310) 3931538..3932731 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KZ665_RS19375 (KZ665_19315) 3932754..3935900 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
KZ665_RS19380 (KZ665_19320) 3936386..3936760 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KZ665_RS19385 (KZ665_19325) 3936787..3937005 + 219 WP_002892050.1 HHA domain-containing protein Toxin
KZ665_RS19390 (KZ665_19330) 3937164..3937730 + 567 WP_002892030.1 maltose O-acetyltransferase -
KZ665_RS19395 (KZ665_19335) 3937702..3937842 - 141 WP_004147370.1 hypothetical protein -
KZ665_RS19400 (KZ665_19340) 3937863..3938333 + 471 WP_002892026.1 YlaC family protein -
KZ665_RS19405 (KZ665_19345) 3938308..3939759 - 1452 WP_223051099.1 PLP-dependent aminotransferase family protein -
KZ665_RS19410 (KZ665_19350) 3939860..3940558 + 699 WP_002892021.1 GNAT family protein -
KZ665_RS19415 (KZ665_19355) 3940555..3940695 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KZ665_RS19420 (KZ665_19360) 3940695..3940958 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T213773 WP_002892050.1 NZ_CP081896:3936787-3937005 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T213773 NZ_CP109850:2226999-2227280 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT213773 WP_002892066.1 NZ_CP081896:3936386-3936760 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT213773 NZ_CP109850:2226775-2227002 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAAGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAGCACGCCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References