Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 789213..789870 Replicon chromosome
Accession NZ_CP081896
Organism Klebsiella pneumoniae strain PA-01

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KZ665_RS03900 Protein ID WP_002916310.1
Coordinates 789460..789870 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KZ665_RS03895 Protein ID WP_002916312.1
Coordinates 789213..789479 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ665_RS03870 (KZ665_03870) 784370..785803 - 1434 WP_032418366.1 6-phospho-beta-glucosidase -
KZ665_RS03875 (KZ665_03875) 785921..786649 - 729 WP_102098506.1 MurR/RpiR family transcriptional regulator -
KZ665_RS03880 (KZ665_03880) 786699..787010 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KZ665_RS03885 (KZ665_03885) 787174..787833 + 660 WP_002916317.1 hemolysin III family protein -
KZ665_RS03890 (KZ665_03890) 787984..788967 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KZ665_RS03895 (KZ665_03895) 789213..789479 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KZ665_RS03900 (KZ665_03900) 789460..789870 + 411 WP_002916310.1 protein YgfX Toxin
KZ665_RS03905 (KZ665_03905) 789877..790398 - 522 WP_002916308.1 flavodoxin FldB -
KZ665_RS03910 (KZ665_03910) 790499..791395 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KZ665_RS03915 (KZ665_03915) 791418..792131 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KZ665_RS03920 (KZ665_03920) 792137..793870 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T213762 WP_002916310.1 NZ_CP081896:789460-789870 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T213762 NZ_CP109846:c4574742-4574029 [Providencia rettgeri]
GTGACTTTATTCGCTCAAGTACTGGGGCTCATCAGTTTAAATGATGTGCCCCATAGTTTTATTTTAAATGTAGGTGAAAT
AAAGGCGTTAGCGGTTGAACGTTTTGAGCGTAAATATTCTTCTGATTCCTCGTGGATTATGCGTTTACCACAAGAAGATT
TTTGTCAAACATTGAATATTTCACCGGCAAGAAAATATCAAAATCATGGTGGACCGGGTATTTCTGAAATTATGAATTAT
TTATTAGGTTCAATAAATGCAGAGAAAGATAGATATCAGTTTATGAAGAGCCAGGTTTTGTTTTGGTTACTTGCAGCGAC
GGATGGCCATGCTAAAAATTTTTCATTATTTATTGAACCTGAAGGCCGTTATCAGTTAACACCTTTTTACGATATTTTGT
CCATGTATCCTAGTTATGGGGGGAGGGGAATTAACCCTAGAGATGCCAAATTGGCTATGGGGCTGAAGGGAACAAGGGAG
ATGAAATACAATATAGAGCAAATTTTTCCAAGGCATTTTTTTGCAACGGCCAAGGAGGTTGGTTTTGACCGCACTGAAAT
GGAAAAAATCTTAATTGAGTTTGATGAGCAAATGGAGAGTGTTATTACAAAGGTTAGGGAACAGCTTCCAACCAATTTCC
CTAAGCACATTGCAGACTCAATTTTATCAGGGTTACATCATAAAGCCGCACGATTAAAAAAAGGTTGGGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT213762 WP_002916312.1 NZ_CP081896:789213-789479 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT213762 NZ_CP109846:c4575039-4574782 [Providencia rettgeri]
ATGAAAGTGACCAATACCCGACAACTTAGTGCTTACATGAAAGATGTCAGAGAGACGAAAAAATTATCTCAAAGTAAAGT
GGGTATTCGGCAAGATACCGTCTCCAGTTTTGAACTCTCTCCTGACTCTACCAAATTAGAAACCTTCTTTAAGATTTTAT
CTGCCCTAAATTTAGAACTCGATATTAAACCGCGAAATGAAAGTGGCTCATCAAACTCAAACTCAAATTCAAACTCTGGA
TGGAAGGAGGAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References