Detailed information of TA system TA021376

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 1254632..1255206
• Replicon: chromosome
• Accession: NC_007643
• Organism: Rhodospirillum rubrum ATCC 11170

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q2RVI2
• Locus tag: RRU_RS05550
• Protein ID: WP_011388817.1
• Coordinates: 1254841..1255206 (+)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q2RVI3
• Locus tag: RRU_RS05545
• Protein ID: WP_011388816.1
• Coordinates: 1254632..1254847 (+)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RRU_RS05515	1249831..1250835	-	1005	WP_011388811.1	NAD(P)H-quinone oxidoreductase	-
RRU_RS05520	1250984..1251166	+	183	WP_014626086.1	DUF1192 family protein	-
RRU_RS05525	1251265..1252044	+	780	WP_011388812.1	3-hydroxybutyrate dehydrogenase	-
RRU_RS05530	1252054..1252509	+	456	WP_011388813.1	acyl-CoA thioesterase	-
RRU_RS05535	1252513..1253496	-	984	WP_011388814.1	aldo/keto reductase	-
RRU_RS05540	1253602..1254537	+	936	WP_011388815.1	LysR family transcriptional regulator	-
RRU_RS05545	1254632..1254847	+	216	WP_011388816.1	ribbon-helix-helix domain-containing protein	Antitoxin
RRU_RS05550	1254841..1255206	+	366	WP_011388817.1	type II toxin-antitoxin system VapC family toxin	Toxin
RRU_RS05555	1255244..1255588	+	345	WP_011388818.1	transcriptional regulator	-
RRU_RS05560	1255763..1256059	+	297	WP_011388819.1	type II toxin-antitoxin system RelE/ParE family toxin	-
RRU_RS05565	1256068..1256376	+	309	WP_014626089.1	HigA family addiction module antidote protein	-
RRU_RS05570	1256531..1257316	+	786	WP_011388821.1	ATP-binding cassette domain-containing protein	-
RRU_RS05575	1257313..1258014	+	702	WP_011388822.1	cobalamin biosynthesis protein	-
RRU_RS05580	1258016..1259197	+	1182	WP_011388823.1	cysteine desulfurase	-
RRU_RS05585	1259241..1259966	+	726	WP_011388824.1	Fe-S cluster protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-106)

Antitoxin

• Ribbon-helix-helix protein, CopG (7-40)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 13667.80 Da
• Isoelectric Point: 5.7614

>T21376 WP_011388817.1 NC_007643:1254841-1255206 [Rhodospirillum rubrum ATCC 11170]
MVGALFDTNILIDHLNARPEASEEIERFESRAISIITWMEVMVGARADLIEPTRLFLDGFKVIALDDKIAKRAVDLRRAH
RIKLPDAVIWATAQTTGRLLVTRNTKDFPPDDPGVREPYAL

Nucleotide

• Length: 366 bp

>T21376 NC_007643:1254841-1255206 [Rhodospirillum rubrum ATCC 11170]
ATGGTAGGCGCGCTTTTCGATACCAATATCCTCATCGATCATCTGAACGCCCGCCCCGAGGCTAGCGAGGAAATCGAGCG
ATTTGAGAGTCGCGCCATCAGCATCATCACATGGATGGAGGTGATGGTGGGCGCGCGCGCCGATCTGATAGAGCCGACCC
GGCTTTTTCTCGACGGCTTCAAAGTCATCGCATTGGACGACAAGATCGCCAAGCGCGCGGTGGACTTGCGGCGCGCCCAT
CGCATTAAACTGCCTGACGCGGTGATCTGGGCCACGGCGCAGACCACCGGACGCTTGCTTGTGACCCGCAACACCAAGGA
CTTTCCGCCCGACGATCCGGGGGTACGCGAACCCTACGCCTTGTAG

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 8038.06 Da
• Isoelectric Point: 7.2023

>AT21376 WP_011388816.1 NC_007643:1254632-1254847 [Rhodospirillum rubrum ATCC 11170]
VRALVDMSDAQIEALDTLAKRVGQSRAALIRAAIDDYLDRHHREQVADGFGLWGKRKVDGLAYQEKARSEW

Nucleotide

• Length: 216 bp

>AT21376 NC_007643:1254632-1254847 [Rhodospirillum rubrum ATCC 11170]
GTGAGAGCCCTTGTCGATATGAGCGATGCCCAGATCGAAGCCCTCGACACCCTTGCCAAGCGGGTGGGCCAGTCGCGTGC
CGCGCTGATCAGGGCGGCGATAGACGATTATCTAGATCGTCATCACCGCGAACAGGTCGCGGACGGTTTCGGCCTTTGGG
GCAAGCGCAAGGTCGATGGTCTGGCCTATCAGGAGAAGGCGCGCAGCGAATGGTAG

Structures

Toxin

• AlphaFold DB: Q2RVI2

Antitoxin

• AlphaFold DB: Q2RVI3