Detailed information of TA system TA213759

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4661671..4662142
• Replicon: chromosome
• Accession: NZ_CP081895
• Organism: Klebsiella quasipneumoniae strain MN-07

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KZ661_RS22675
• Protein ID: WP_130941649.1
• Coordinates: 4661671..4661910 (-)
• Length: 80 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1C1EW86
• Locus tag: KZ661_RS22680
• Protein ID: WP_023291757.1
• Coordinates: 4661900..4662142 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KZ661_RS22665 (4658600)	4658600..4660738	+	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
KZ661_RS22670 (4661158)	4661158..4661622	+	465	WP_012969085.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
KZ661_RS22675 (4661671)	4661671..4661910	-	240	WP_130941649.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KZ661_RS22680 (4661900)	4661900..4662142	-	243	WP_023291757.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KZ661_RS22685 (4662220)	4662220..4664130	-	1911	WP_223064063.1	PRD domain-containing protein	-
KZ661_RS22690 (4664153)	4664153..4665304	-	1152	WP_023291755.1	lactonase family protein	-
KZ661_RS22695 (4665371)	4665371..4666111	-	741	WP_004206507.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-76)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-70)

Sequences

Toxin

Protein

• Length: 80 a.a.
• Molecular weight: 9136.63 Da
• Isoelectric Point: 10.1315

>T213759 WP_130941649.1 NZ_CP081895:c4661910-4661671 [Klebsiella quasipneumoniae]
MTYELAFDPRAWREWQKLGETIKKQFKNKLQQVVQNPRIASASLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIASG

Nucleotide

• Length: 240 bp

>T213759 NZ_CP109846:1597673-1598083 [Providencia rettgeri]
GTGGTCCTGTGGAAATCTAATCTTTCCATTTCATGGAAAACACAGTTTTTTTCAACCTGTGTTCATGGGGCAGTAGGCAT
GTTTTTGCTTGTTGCACCATGGGCACCGGCTCATTCAATGATATGGTTGCCACTTCTTGCGGTTGTGGTGGCTAGTTGGG
CAAAAAGCCAAAAGAACATCAGCAAAATAAAAGGGGTTGCTGTGTTGGTTAATGGTAATAAAGTCCAATGGAAAAAGAAT
GAATGGAATATTGTGAAAGCACCTTGGTTGAGCCGCTATGGCATCTTATTGTCATTAGAAGCTTTACAAGGTAAGCAACA
AAAAATTCACCTATGGGTTGCTAAAGACTCTGTTTCTGAGGAAAGTTGGCGTAATTTGAACCAATTATTACTTCAATACC
CTGATATTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9119.58 Da
• Isoelectric Point: 4.8146

>AT213759 WP_023291757.1 NZ_CP081895:c4662142-4661900 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDSEAALLRTVRERLENPQPEVKVSLDDL

Nucleotide

• Length: 243 bp

>AT213759 NZ_CP109846:1597426-1597692 [Providencia rettgeri]
ATGGATATTGAGAACAAGGCGCGAATTCATTGGGCTTGTCGCCGCGGTATGCGTGAGCTAGATATTTCAATCATGCCATT
TTTTGAGTATGAATATGATAGTCTGACAACCAATGATAAACAGGTGTTTGTCCGTTTATTGGAGTGTGCGGACCCTGATT
TATTTAACTGGTTAATGAATCACGGTCGCCCAGATGACGACGAGCTATTTCGTATGGTAAAACTGATTCAGGAAAAAAAT
AAAAATCGTGGTCCTGTGGAAATCTAA

Structures

Antitoxin

• AlphaFold DB: A0A1C1EW86