Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3910568..3911187 Replicon chromosome
Accession NZ_CP081895
Organism Klebsiella quasipneumoniae strain MN-07

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KZ661_RS19215 Protein ID WP_002892050.1
Coordinates 3910969..3911187 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KZ661_RS19210 Protein ID WP_002892066.1
Coordinates 3910568..3910942 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ661_RS19200 (3905722) 3905722..3906915 + 1194 WP_023288645.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KZ661_RS19205 (3906938) 3906938..3910084 + 3147 WP_023288644.1 multidrug efflux RND transporter permease subunit AcrB -
KZ661_RS19210 (3910568) 3910568..3910942 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KZ661_RS19215 (3910969) 3910969..3911187 + 219 WP_002892050.1 HHA domain-containing protein Toxin
KZ661_RS19220 (3911346) 3911346..3911912 + 567 WP_023288643.1 maltose O-acetyltransferase -
KZ661_RS19225 (3911884) 3911884..3912015 - 132 WP_162543094.1 hypothetical protein -
KZ661_RS19230 (3912049) 3912049..3912519 + 471 WP_064155186.1 YlaC family protein -
KZ661_RS19235 (3912488) 3912488..3913945 - 1458 WP_087827730.1 PLP-dependent aminotransferase family protein -
KZ661_RS19240 (3914046) 3914046..3914744 + 699 WP_044521289.1 GNAT family protein -
KZ661_RS19245 (3914741) 3914741..3914881 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KZ661_RS19250 (3914881) 3914881..3915144 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T213758 WP_002892050.1 NZ_CP081895:3910969-3911187 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T213758 NZ_CP109846:c934443-934240 [Providencia rettgeri]
ATGACCAAATCTGATTATCTGATGCGTTTGAGAAAATGCACAACAATTGAAACACTTGAGCGTGTCATTGAAAAAAACAA
GTATGAACTATCTGATGATGAACTAGAGTTATTCTACTCAGCGGCAGATCATCGTCTTGCTGAACTCACTATGAATAAGC
TCTACGATAAAATTCCACCTTCTGTATGGAAGTTTGTTAGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT213758 WP_002892066.1 NZ_CP081895:3910568-3910942 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT213758 NZ_CP109846:c934886-934518 [Providencia rettgeri]
ATGGATGAATACTCACCCAAAAGACATGATATAGCAGAACTAAAATACTTATGTAACAGTCTCAATAGAGACGCTATCTT
AAGTTTGCAAAAAACCAATACACATTGGATTAACGATCTAAGCTCTGCACAAAGTGCAGCTCTAAATGAACTCATTGAAC
ATATCGCAGCTTTTGTCTGGCGATTTAAGATCAAATATCCAAAAGAAAATCTCGTTATATCATTAATTGAAGAGTACCTC
GATGAGACTTATGACTTATTTGGTAGCCCAGTCATCACATTAAGTGAAATTATAGATTGGGAAACTATGAATCAAAATCT
AGTTTCAGTGCTGGATGATGACCTAAAATGTCTGACCAGCAAAACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References