Detailed information of TA system TA021375

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): slvAT/RES(toxin)
• Location: 969912..970804
• Replicon: chromosome
• Accession: NC_007643
• Organism: Rhodospirillum rubrum ATCC 11170

Toxin (Protein)

• Gene name: slvT
• Uniprot ID: Q2RW79
• Locus tag: RRU_RS04275
• Protein ID: WP_011388570.1
• Coordinates: 969912..970436 (-)
• Length: 175 a.a.

Antitoxin (Protein)

• Gene name: slvA
• Uniprot ID: Q2RW78
• Locus tag: RRU_RS04280
• Protein ID: WP_011388571.1
• Coordinates: 970433..970804 (-)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RRU_RS04260	966643..966933	+	291	WP_011388568.1	DCL family protein	-
RRU_RS04265	967217..967687	-	471	WP_011388569.1	ribbon-helix-helix domain-containing protein	-
RRU_RS04270	967695..969686	-	1992	Protein_828	conjugal transfer protein TraG	-
RRU_RS04275	969912..970436	-	525	WP_011388570.1	RES family NAD+ phosphorylase	Toxin
RRU_RS04280	970433..970804	-	372	WP_011388571.1	DUF2384 domain-containing protein	Antitoxin
RRU_RS04285	970931..972688	-	1758	WP_014626034.1	VirD2 family relaxase/mobilization nuclease	-
RRU_RS04290	973154..973960	+	807	Protein_832	IS256 family transposase	-
RRU_RS04295	974004..974225	-	222	Protein_833	transposase family protein	-
RRU_RS04300	974735..974887	+	153	WP_158308117.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	973250..973960	710

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (15-158)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (71-120)

Sequences

Toxin

Protein

• Length: 175 a.a.
• Molecular weight: 19612.07 Da
• Isoelectric Point: 4.8129

>T21375 WP_011388570.1 NC_007643:c970436-969912 [Rhodospirillum rubrum ATCC 11170]
MIVRTLGTELPEAYYRVITPEYAGTPKSGRGAARRGGRFNRPQQEALYLSANDVTALAEYKQDNPWLRPGTICTFFVAGL
HVADLSDGFDPAHWPSLWADFTIDWRAEWFDKGIEPPTWYMADDVVSADLDGILFPSQALSGGVNLVIYRSSERPETQLS
VYDPDRQLKKITLR

Nucleotide

• Length: 525 bp

>T21375 NC_007643:c970436-969912 [Rhodospirillum rubrum ATCC 11170]
ATGATTGTCCGGACTCTGGGAACCGAACTGCCCGAGGCCTACTACAGAGTCATCACCCCTGAATATGCCGGCACCCCCAA
GTCGGGCAGGGGAGCGGCCCGACGTGGTGGCCGGTTCAACCGCCCCCAACAGGAAGCACTCTATCTGTCGGCCAACGACG
TAACCGCACTGGCGGAGTACAAGCAGGACAATCCTTGGCTCCGCCCCGGCACGATCTGTACCTTCTTTGTCGCCGGACTG
CACGTAGCCGACCTCAGCGACGGCTTCGACCCGGCGCACTGGCCCAGCCTGTGGGCGGATTTTACCATCGACTGGCGGGC
GGAGTGGTTTGACAAGGGGATCGAACCGCCAACTTGGTATATGGCCGACGACGTGGTGAGTGCTGACTTGGACGGCATCC
TCTTTCCCTCCCAGGCCTTGTCTGGGGGTGTCAATCTCGTGATCTACCGCAGCTCCGAGCGACCGGAAACGCAATTGAGC
GTCTACGACCCGGATAGACAGCTAAAGAAAATCACGCTTCGGTAG

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13578.41 Da
• Isoelectric Point: 7.2025

>AT21375 WP_011388571.1 NC_007643:c970804-970433 [Rhodospirillum rubrum ATCC 11170]
MSPLFSEPLAERFREANTPYLSPAKVSELFGFRVQELAGRAHVHRNTPTARPQTPQLQQYLQNMVRVLTVATEMTGDEGR
AVFLLRNEPLRAFGYKTADTLVQEGRADAVIAYLESLTGGAAG

Nucleotide

• Length: 372 bp

>AT21375 NC_007643:c970804-970433 [Rhodospirillum rubrum ATCC 11170]
ATGAGCCCCCTGTTTTCAGAACCCCTGGCTGAGCGATTCCGCGAAGCGAATACTCCCTATCTCTCGCCCGCCAAGGTGAG
TGAGCTTTTCGGCTTCCGCGTCCAGGAACTGGCCGGGCGCGCGCACGTGCATCGCAATACCCCCACCGCACGCCCGCAGA
CACCGCAGTTGCAGCAATACCTGCAAAACATGGTGCGGGTGCTGACCGTGGCGACCGAGATGACCGGCGACGAGGGGCGT
GCGGTTTTCCTCCTCCGCAATGAACCGCTCCGGGCCTTCGGCTACAAGACCGCCGATACCTTGGTCCAAGAGGGCCGCGC
CGACGCGGTCATCGCCTACCTGGAATCGCTGACCGGCGGCGCCGCCGGATGA

Structures

Toxin

• AlphaFold DB: Q2RW79

Antitoxin

• AlphaFold DB: Q2RW78