Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 726375..727153 Replicon chromosome
Accession NZ_CP081895
Organism Klebsiella quasipneumoniae strain MN-07

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag KZ661_RS03665 Protein ID WP_087826665.1
Coordinates 726665..727153 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag KZ661_RS03660 Protein ID WP_049014236.1
Coordinates 726375..726668 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ661_RS03640 (721598) 721598..722200 - 603 WP_032454058.1 short chain dehydrogenase -
KZ661_RS03645 (722298) 722298..723209 + 912 WP_044524712.1 LysR family transcriptional regulator -
KZ661_RS03650 (723210) 723210..724358 - 1149 WP_087826667.1 PLP-dependent aspartate aminotransferase family protein -
KZ661_RS03655 (724369) 724369..725745 - 1377 WP_165454422.1 cystathionine beta-synthase -
KZ661_RS03660 (726375) 726375..726668 + 294 WP_049014236.1 DUF1778 domain-containing protein Antitoxin
KZ661_RS03665 (726665) 726665..727153 + 489 WP_087826665.1 GNAT family N-acetyltransferase Toxin
KZ661_RS03670 (727464) 727464..727715 - 252 WP_087826663.1 hypothetical protein -
KZ661_RS03675 (727887) 727887..731927 - 4041 WP_087826662.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 720779..731927 11148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17524.37 Da        Isoelectric Point: 7.7539

>T213745 WP_087826665.1 NZ_CP081895:726665-727153 [Klebsiella quasipneumoniae]
MISAPEPLHAGHILTPFCCGVDSMDNWLKLRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPVVVLGRLAVDRSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLV
HA

Download         Length: 489 bp

>T213745 NZ_CP109844:c145208-144927 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10914.54 Da        Isoelectric Point: 9.8590

>AT213745 WP_049014236.1 NZ_CP081895:726375-726668 [Klebsiella quasipneumoniae]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIILADPQAYQEFLARLDQTPAPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT213745 NZ_CP109844:c145432-145205 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References