Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4016266..4016885 Replicon chromosome
Accession NZ_CP081894
Organism Klebsiella pneumoniae strain NC-01

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KZ666_RS19710 Protein ID WP_002892050.1
Coordinates 4016667..4016885 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KZ666_RS19705 Protein ID WP_002892066.1
Coordinates 4016266..4016640 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KZ666_RS19695 (4011418) 4011418..4012611 + 1194 WP_223059139.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KZ666_RS19700 (4012634) 4012634..4015780 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
KZ666_RS19705 (4016266) 4016266..4016640 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KZ666_RS19710 (4016667) 4016667..4016885 + 219 WP_002892050.1 HHA domain-containing protein Toxin
KZ666_RS19715 (4017044) 4017044..4017610 + 567 WP_002892030.1 maltose O-acetyltransferase -
KZ666_RS19720 (4017582) 4017582..4017722 - 141 WP_004147370.1 hypothetical protein -
KZ666_RS19725 (4017743) 4017743..4018213 + 471 WP_002892026.1 YlaC family protein -
KZ666_RS19730 (4018188) 4018188..4019639 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
KZ666_RS19735 (4019740) 4019740..4020438 + 699 WP_002892021.1 GNAT family protein -
KZ666_RS19740 (4020435) 4020435..4020575 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KZ666_RS19745 (4020575) 4020575..4020838 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T213740 WP_002892050.1 NZ_CP081894:4016667-4016885 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T213740 NZ_CP109843:1348210-1348629 [Pseudomonas aeruginosa]
ATGATTGTCTTGGATACGAATGTCGTCTCCGAGGCGATGAAGCCCGAACCCAACCCGGCCGTGCGAGCTTGGTTGAATGA
GCAGGTAGTGGAAACCCTCTACCTGTCCAGCGTGACGCTGGCCGAGCTGCTGTTCGGCATCGGCGCGCTTCCGAACGGGA
AACGTAAGAAAGGCCTGGGCGAAGCCCTGGACGGCTTGCTCGAGCTGTTCGGCGAGCGGGTGCTGATGTTCGACACCGAA
GCAGCTCGCCATTATGCCGAGCTTGCGGTGAAGGCCCGCACAGCCGGAAAGGGTTTCCCAACACCCGACGGATATATTGG
GGCTATTGCGGCCTCCAAGGGATTTATCGTAGCAACACGCGACACCAGCCCTTTTGAAGCGGCTGGGCTTACTGTTATCA
ATCCTTGGAACCATCAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT213740 WP_002892066.1 NZ_CP081894:4016266-4016640 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT213740 NZ_CP109843:1347959-1348213 [Pseudomonas aeruginosa]
ATGGCAATCCTGACAGTGCGGAATGTGCCGGACGAGGTGCATCGCGCTCTGCGCTTACGGGCCGCCGAGCATGGCCGCAG
TACAGAGGCGGAGGTGCGCGAGATTCTGGAAAGTGCAGTGAAGTCGGAAAAGCGCATCCGCATGGGCGACGCGTTGGCGG
AGCTTGGCCGCCGCGTAGGGCTGACAAACGACGACTTCGCAGTATTGGACCAGGTGCGCGACAAGGTGCCGGCAGAACCG
ATGAGGTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References