Detailed information of TA system TA021374

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/COG3657-DUF971
• Location: 536569..537154
• Replicon: chromosome
• Accession: NC_007643
• Organism: Rhodospirillum rubrum ATCC 11170

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: Q2RX83
• Locus tag: RRU_RS02405
• Protein ID: WP_011388216.1
• Coordinates: 536858..537154 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: Q2RX84
• Locus tag: RRU_RS02400
• Protein ID: WP_011388215.1
• Coordinates: 536569..536856 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RRU_RS02390	534503..536005	+	1503	WP_011388213.1	leucyl aminopeptidase	-
RRU_RS02395	536043..536558	+	516	WP_011388214.1	NUDIX pyrophosphatase	-
RRU_RS02400	536569..536856	-	288	WP_011388215.1	putative addiction module antidote protein	Antitoxin
RRU_RS02405	536858..537154	-	297	WP_011388216.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
RRU_RS02410	537511..538188	+	678	WP_011388217.1	energy-coupling factor ABC transporter permease	-
RRU_RS02415	538508..539215	+	708	WP_081467687.1	PD-(D/E)XK nuclease family protein	-
RRU_RS02420	539217..539894	+	678	WP_014625944.1	hypothetical protein	-
RRU_RS02425	540016..540642	-	627	WP_011388219.1	NAD(P)-binding domain-containing protein	-
RRU_RS02430	540748..541641	+	894	WP_011388220.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-94)

Antitoxin

• Uncharacterized protein HI1420 (3-93)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11036.68 Da
• Isoelectric Point: 10.6462

>T21374 WP_011388216.1 NC_007643:c537154-536858 [Rhodospirillum rubrum ATCC 11170]
MIELKQTETFRKWRTRLKDVRARAIIAARLDRLSQGHTGDSEPVGDGISELRIHYGPGYRLSFQKRGQTIVVLLCGGDKS
TQAKDIQTAKRLAEIGKE

Nucleotide

• Length: 297 bp

>T21374 NC_007643:c537154-536858 [Rhodospirillum rubrum ATCC 11170]
ATGATCGAGCTAAAGCAAACCGAGACCTTTCGCAAATGGCGGACGCGCCTCAAAGACGTCCGAGCCAGGGCGATCATCGC
CGCCCGTCTCGACCGGCTTTCCCAAGGTCACACCGGCGATAGTGAACCGGTGGGCGATGGGATCAGCGAGCTGCGCATTC
ATTATGGTCCCGGCTATCGCCTCTCTTTCCAGAAGCGGGGACAGACGATCGTCGTTCTGCTGTGCGGTGGGGACAAGAGC
ACCCAGGCCAAAGACATCCAAACGGCGAAACGCTTGGCCGAGATAGGGAAAGAGTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10266.70 Da
• Isoelectric Point: 4.5680

>AT21374 WP_011388215.1 NC_007643:c536856-536569 [Rhodospirillum rubrum ATCC 11170]
MTETLTPYDPAEDLVSDEAVAVFMTEAFKTEDAAYIAHALGVVARAKGMTQIAKDTGLSREQLYRSFSENGNPTLKTTLA
VMKSLGIELTVKPQA

Nucleotide

• Length: 288 bp

>AT21374 NC_007643:c536856-536569 [Rhodospirillum rubrum ATCC 11170]
ATGACCGAAACGCTGACGCCTTATGATCCGGCCGAGGACTTGGTTTCCGACGAGGCGGTTGCCGTCTTCATGACGGAAGC
CTTCAAAACCGAGGACGCCGCTTATATCGCCCATGCCCTTGGGGTCGTCGCCCGCGCCAAGGGCATGACGCAGATCGCCA
AGGATACGGGGCTTTCCCGCGAGCAGCTTTACCGCTCCTTCAGCGAAAATGGCAATCCAACGCTGAAAACGACGCTCGCC
GTCATGAAATCGCTCGGCATCGAATTGACGGTGAAACCCCAGGCCTGA

Structures

Toxin

• AlphaFold DB: Q2RX83

Antitoxin

• AlphaFold DB: Q2RX84