Detailed information of TA system TA021373

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 104817..105497
• Replicon: chromosome
• Accession: NC_007643
• Organism: Rhodospirillum rubrum ATCC 11170

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q2RY99
• Locus tag: RRU_RS00460
• Protein ID: WP_011387852.1
• Coordinates: 105063..105497 (+)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q2RYA0
• Locus tag: RRU_RS00455
• Protein ID: WP_011387851.1
• Coordinates: 104817..105059 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RRU_RS00440	100089..101330	+	1242	WP_011387848.1	TIGR03862 family flavoprotein	-
RRU_RS00445	101509..102531	+	1023	WP_011387849.1	zinc-binding alcohol dehydrogenase family protein	-
RRU_RS00450	102652..104541	+	1890	WP_011387850.1	DNA helicase RecQ	-
RRU_RS00455	104817..105059	+	243	WP_011387851.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
RRU_RS00460	105063..105497	+	435	WP_011387852.1	type II toxin-antitoxin system VapC family toxin	Toxin
RRU_RS00465	105873..107150	+	1278	WP_011387853.1	ABC transporter substrate-binding protein	-
RRU_RS00470	107196..108065	+	870	WP_011387854.1	sugar ABC transporter permease	-
RRU_RS00475	108062..109000	+	939	WP_011387855.1	carbohydrate ABC transporter permease	-
RRU_RS00480	109007..110125	+	1119	WP_011387856.1	sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-132)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-57)

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15675.14 Da
• Isoelectric Point: 7.4700

>T21373 WP_011387852.1 NC_007643:105063-105497 [Rhodospirillum rubrum ATCC 11170]
MYLVDTNVLSARAPSRVAPVELIAWMDAHSAELFLSAVTVAEIEDGIAKLRREGATRKAADLMAWLDALLHLYGNRILPF
DTTLARLAGVLSDRARAQGQAPGFADIAIAATAKHHDLTILTRNVRHFDRLGVPVIDPFAALPR

Nucleotide

• Length: 435 bp

>T21373 NC_007643:105063-105497 [Rhodospirillum rubrum ATCC 11170]
TTGTATCTGGTCGACACCAACGTTCTGTCGGCCAGGGCGCCGTCACGGGTCGCCCCGGTCGAACTGATCGCCTGGATGGA
CGCCCATTCGGCGGAGCTTTTCCTCTCGGCGGTGACGGTGGCGGAAATCGAGGACGGCATCGCCAAGCTGCGTCGCGAAG
GCGCGACGCGCAAGGCGGCCGATCTGATGGCATGGCTGGACGCGCTGCTGCATCTCTATGGCAACCGCATCCTGCCGTTC
GACACGACCCTCGCGCGCCTGGCCGGCGTGCTTTCCGACCGGGCGCGGGCGCAAGGCCAGGCGCCGGGTTTTGCCGACAT
CGCCATCGCGGCGACGGCCAAACACCACGACCTGACGATCCTGACCCGCAACGTTCGCCACTTCGACCGCTTGGGCGTGC
CGGTGATCGATCCCTTCGCGGCGTTGCCCCGGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8844.18 Da
• Isoelectric Point: 7.0141

>AT21373 WP_011387851.1 NC_007643:104817-105059 [Rhodospirillum rubrum ATCC 11170]
MREIQLRDAKARLSAVVDDAVRGEPAIITRHGKREAVVLSFAEWERLSQVPSFGRLLMSAPLAPDDLPPRNEAPLRDAGL

Nucleotide

• Length: 243 bp

>AT21373 NC_007643:104817-105059 [Rhodospirillum rubrum ATCC 11170]
ATGCGCGAAATTCAGCTTCGGGACGCCAAGGCCCGCCTGTCGGCGGTGGTTGACGACGCGGTGCGCGGCGAGCCGGCTAT
CATCACCCGGCATGGCAAGCGGGAGGCCGTGGTTCTGAGCTTCGCCGAGTGGGAGCGTCTTTCACAGGTGCCCTCTTTCG
GCCGTTTGCTGATGAGCGCGCCGCTGGCGCCCGACGATCTGCCGCCCCGAAACGAAGCGCCGCTGCGCGATGCCGGGCTC
TGA

Structures

Toxin

• AlphaFold DB: Q2RY99

Antitoxin

• AlphaFold DB: Q2RYA0